3-(TRIFLUOROMETHYL)-5-P-TOLYL-1H-PYRAZOLE synthesis
- Product Name:3-(TRIFLUOROMETHYL)-5-P-TOLYL-1H-PYRAZOLE
- CAS Number:26974-15-2
- Molecular formula:C11H9F3N2
- Molecular Weight:226.2
96107-01-6
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26974-15-2
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Yield:26974-15-2 99%
Reaction Conditions:
with sodium acetate;toluene-4-sulfonic acid hydrazide in ethanol at 80; for 12 h;Schlenk technique;regioselective reaction;
Steps:
General procedure for the preparation of pyrazoles (2)
General procedure: To a 25mL Schlenk were added ketone (0.25mmol), p-toluenesulfonylhydrazide (0.275mmol, 1.1equiv), sodium acetate (0.275mmol, 1.1equiv) and EtOH (2mL). The mixture was stirred at 80°C for 12h and allowed to cool down to room temperature. After removal of the solvent, the residue was purified by column chromatography on silica gel (hexane/EtOAc) or crystallization to afford the pyrazoles 2. The analytical data are in accordance with the literature.9,16-25
References:
Wang, Yongdong;Han, Jing;Chen, Jie;Cao, Weiguo [Tetrahedron,2015,vol. 71,# 43,p. 8256 - 8262]
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