6,7-dimethyl-1H-pteridin-4-one synthesis

Yield:14684-54-9 72%

Reaction Conditions:

in methanol;toluene; for 1 h;Reflux;

Steps:

10

Preparation 10. 6,7-Dimethyl-pteridin-4-ol. A mixture of 6-chloropyrimidine-4,5-diamine (1.4 g, 10 mmol) and 2,3-butanedione (2.0 g, 23 mmol) in toluene (35 mL) and methanol (10 mL) was stirred at reflux for 1 h. Upon cooling, the product precipitated and was collected by suction filtration and rinsed with a MeOH/Et₂O mixture (ca. 1:2), then air dried to afford 6,7-dimethylpteridin-4-ol (1.4 g, 72%) as a gold powder.

References:

US2011/54173,2011,A1 Location in patent:Page/Page column 26