Bexarotene synthesis
- Product Name:Bexarotene
- CAS Number:153559-49-0
- Molecular formula:C24H28O2
- Molecular Weight:348.48

Wagner, Carl E.; Jurutka, Peter W.; Marshall, Pamela A.; Groy, Thomas L.; van der Vaart, Arjan; Ziller, Joseph W.; Furmick, Julie K.; Graeber, Mark E.; Matro, Erik; Miguel, Belinda V.; Tran, Ivy T.; Kwon, Jungeun; Tedeschi, Jamie N.; Moosavi, Shahram; Danishyar, Amina; Philp, Joshua S.; Khamees, Reina O.; Jackson, Jevon N.; Grupe, Darci K.; Badshah, Syed L.; Hart, Justin W. Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene). Journal of Medicinal Chemistry. Division of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences. Arizona State University. Glendale, USA 85306. Volume 52. Issue 19. Pages 5950-5966. 2009
110-03-2
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153559-49-0
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Yield:-
Steps:
Multi-step reaction with 7 steps
1: HCl conc. / 3 h / 20 °C
2: 99 percent / AlCl3 / CH2Cl2 / 20 °C
3: 85 percent / Br2; AlCl3 / CH2Cl2
4: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C
5: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C
6: 88 percent / Pd(OAc)2; P(o-Tol)3; Et3N / dimethylformamide / 2 h / 50 °C
7: H2O
References:
Faul;Ratz;Sullivan;Trankle;Winneroski [Journal of Organic Chemistry,2001,vol. 66,# 17,p. 5772 - 5782]
153559-48-9
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153559-49-0
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6683-48-3
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$8.00/1g
153559-49-0
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153559-45-6
77 suppliers
$145.00/100mg
153559-49-0
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$25.00/5mg
6223-78-5
136 suppliers
$9.00/5g
153559-49-0
300 suppliers
$25.00/5mg








