ChemicalBook CAS DataBase List Deferiprone

Deferiprone synthesis

10synthesis methods

Product Name:Deferiprone
CAS Number:30652-11-0
Molecular formula:C7H9NO2
Molecular Weight:139.15

Deferiprone is a drug that chelates iron and is used to treat thalassaemia major. In 1994 was first approved for use in treating thalassaemia major in 1994 and had been licensed for use in Europe and Asia for many years while awaiting approval in Canada and the United States. On October 14, 2011, it was approved for use in the US under the FDAÂ’s accelerated approval program.

Synthetic Routes

ROUTE 1

ROUTE 2

Dobbin, Paul S.; Hider, Robert C.; Hall, Adrian D.; Taylor, Paul D.; Sarpong, Patience; Porter, John B.; Xiao, Gaoyi; van der Helm, Dick. Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential. Journal of Medicinal Chemistry. Volume 36. Issue 17. Pages 2448-58. Journal. (1993).

118-71-8 Synthesis

118-71-8
649 suppliers
$5.00/25mg

30652-11-0
328 suppliers
$7.00/1g

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 99 percent / KOH / methanol / Ambient temperature
2: 99 percent / ethanol / 22 h / Ambient temperature
3: 80 percent / H₂ / Pd/C / methanol / 2 h

References:

Rumbo, Antonio;Mourino, Antonio;Castedo, Luis;Mascarenas, Jose L. [Journal of Organic Chemistry,1996,vol. 61,# 18,p. 6114 - 6120]

FullText

118-71-8 Synthesis

118-71-8
649 suppliers
$5.00/25mg

74-89-5 Synthesis