DICLOFENAC METHYL ESTER synthesis
- Product Name:DICLOFENAC METHYL ESTER
- CAS Number:15307-78-5
- Molecular formula:C15H13Cl2NO2
- Molecular Weight:310.18
67-56-1
790 suppliers
$7.30/5ml-f
15307-86-5
382 suppliers
$48.00/25g
15307-78-5
100 suppliers
$35.00/10mg
Yield: 96%
Reaction Conditions:
with sulfuric acid for 0.25 h;Reflux;
Steps:
3.1.4.2. Diclofenac Methyl Ester (2)
Diclofenac acid (5 g) was dissolved in methanol (80 mL)with stirring and sulfuric acid (3 mL) was added drop wisewith continuous stirring and the mixture was heated underreflux for 15 min. After completion of the reaction (TLCanalysis), it was cooled to room temperature and poured ontocrushed ice (250 g) to obtain crystalline solid (2) which wasfiltered, washed with water followed by 5% sodium hydrogencarbonate solution, finally with water and dried in air.
References:
Shah, Shazia;Arshia;Kazmi, Nida Siraj;Jabeen, Almas;Khan, Khalid Mohammed;Raza, Abeer;Faheem, Aisha;Dastagir, Nida;Ahmed, Tariq;Ahmed, Shakil;Perveen, Shahnaz [Medicinal Chemistry,2018,vol. 14,# 7,p. 674 - 687]
57486-69-8
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$6.00/1g
608-31-1
317 suppliers
$12.00/25g
15307-78-5
100 suppliers
$35.00/10mg
66370-75-0
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608-31-1
317 suppliers
$12.00/25g
15307-78-5
100 suppliers
$35.00/10mg
15307-79-6
911 suppliers
$14.00/5g
74-88-4
357 suppliers
$15.00/10g
15307-78-5
100 suppliers
$35.00/10mg
15307-86-5
382 suppliers
$48.00/25g
18107-18-1
210 suppliers
$33.00/5g
15307-78-5
100 suppliers
$35.00/10mg