ChemicalBook CAS DataBase List FMOC-L-Methionine

FMOC-L-Methionine synthesis

7synthesis methods

Product Name:FMOC-L-Methionine
CAS Number:71989-28-1
Molecular formula:C20H21NO4S
Molecular Weight:371.45

63-68-3

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1

71989-28-1

Synthesis of Fmoc-L-methionine: 6 mmol of L-methionine and 6.3 mmol of 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) were dissolved in 20 mL of N,N-dimethylformamide (DMF). Subsequently, 6.3 mmol of sodium bicarbonate (NaHCO3) was added to the reaction mixture to neutralize the acid produced during the reaction and to remove the solvent and residual amines. The reaction mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified to afford the target compound Fmoc-L-methionine in 78% yield.

63-68-3 Synthesis

63-68-3
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82911-69-1 Synthesis

82911-69-1
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$7.00/25g

71989-28-1
441 suppliers
$6.41/1 mmol

Yield:71989-28-1 78%

Reaction Conditions:

with sodium hydrogencarbonate in N,N-dimethyl-formamide at 50;

Steps:

S101 Synthesis of Fmoc-methionin
Synthesis of Fmoc-methionine; 6 mmol methionine and6.3 mmol of Fmoc-OSu was added to 20 ml of DMF (N, N-dimethylformamide)Subsequently, 6.3 mmol of NaHCO3 was added to remove the solvent and the remaining amine compound, which was then purified at 50CDried overnight in an empty oven to give 78% product yield;

References:

Southwest Petroleum University;He, Yi;Yang, Ranran;Zhou, Yanqiu;Fan, Yi;Qing, Dayong;Ma, Lan;Zhan, Yingqing;Chen, Zhao CN105622471, 2016, A Location in patent:Paragraph 0019; 0020

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63-68-3 Synthesis

63-68-3
962 suppliers
$5.00/25g