FMoc-Val-Cit-PAB synthesis
- Product Name:FMoc-Val-Cit-PAB
- CAS Number:159858-22-7
- Molecular formula:C33H39N5O6
- Molecular Weight:601.69
159858-21-6
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623-04-1
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159858-22-7
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Yield:159858-22-7 98%
Reaction Conditions:
with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in methanol;dichloromethane at 20; for 18.0833 h;
Steps:
1 Compound 8:
iV-Ethoxycarbonyl-2-ethoxy-l,2-dihydroquinoline (EEDQ, 1.99 g, 8.05 mmol) was added to a solution of p-aminobenzyl alcohol (0.99 g, 8.05 mmol) in dichloromethane (19 mL) and methanol (7.6 mL) at room temperature. After stirring for 5 min, Fmoc-Valine-Citrulline 7 (2.0 g, 4.03 mmol) was added in one portion and the resulting solution was stirred for 18 hours. Volatiles were removed in vacuo and the residue was triturated with ether (20 mL) and washed sequentially with ether (20 mL), ethyl acetate (20 mL), and ether (20 mL) to get title compound 8 (2.2 g, 98% yield) as a light yellowish solid. MS (ESI, pos.): calc’d for C33H39N5O6, 601.29; found 602.3 (M+H).
References:
WO2021/151031,2021,A1 Location in patent:Paragraph 00181; 00187-00188
1037794-22-1
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68858-20-8
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159858-22-7
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$15.00/25MG
1037794-22-1
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130878-68-1
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159858-22-7
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159857-79-1
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82911-69-1
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159858-22-7
220 suppliers
$15.00/25MG
68858-20-8
548 suppliers
$8.00/1g
159858-22-7
220 suppliers
$15.00/25MG