Methyl 1-Aminocyclopropanecarboxylate synthesis
- Product Name:Methyl 1-Aminocyclopropanecarboxylate
- CAS Number:72784-43-1
- Molecular formula:C5H9NO2
- Molecular Weight:115.13
67-56-1
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72784-43-1
Sulfoxide chloride (8.8 g, 75.1 mmol) was slowly added dropwise to methanol (50 mL) at 0 °C, followed by a one-time addition of 1-aminocyclopropanecarboxylic acid (5.0 g, 49.8 mmol). The reaction mixture was heated to reflux for 1 to 3 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford methyl 1-aminocyclopropanecarboxylate hydrochloride (5.8 g, 100% yield).
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Yield: 100%
Reaction Conditions:
with thionyl chloride at 0;Reflux;
Steps:
15.O.a
To MeOH (50 mL) was added SOCl2 (8.8 g, 75.1 mmol) dropwise at 0 °C, followed by the addition of 1-aminocyclopropanecarboxylic acid (5.0 g, 49.8 mmol) in one portion. The resulting mixture was refluxed for 1 to 3 h. The reaction solution was concentrated under reduced pressure to give a salt of the title compound (5.8 g, 100%).
References:
SUNOVION PHARMACEUTICALS, INC.;PSYCHOGENICS INC.;SHAO, Liming;CAMPBELL, John, Emerson;HEWITT, Michael, Charles;CAMPBELL, Una;HANANIA, Taleen, G. WO2011/69063, 2011, A2 Location in patent:Page/Page column 84
![Cyclopropanecarboxylic acid, 1-[(diphenylmethylene)amino]-, methyl ester](http://hg.y866.cn/chemistry/CAS/20210305/GIF/145618-70-8.gif)
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![Cyclopropanecarboxylic acid, 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, methyl ester](http://hg.y866.cn/chemistry/CAS/20210305/GIF/914223-82-8.gif)
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72784-43-1
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$55.00/250mg