METHYL 3-IODO-4-METHOXYBENZOATE synthesis
- Product Name:METHYL 3-IODO-4-METHOXYBENZOATE
- CAS Number:35387-93-0
- Molecular formula:C9H9IO3
- Molecular Weight:292.07
15126-06-4
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74-88-4
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35387-93-0
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Yield: 88.4%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 60; for 2 h;
Steps:
14.A Step A
Methyl 3-iodo-4-hydroxybenzoate (4.1 g, 14.75 mmol) was dissolved in DMF (25 mL). Potassium carbonate (2.65 g, 19.20 mmol) and methyl iodide (3.14 g, 22.12 mmol) were added. The resulting mixture was stirred at 60 ° C for 2 hours. Cooled to room temperature. Water (80 mL) was added. Extraction with ethyl acetate (40 mL x 3). The combined organic phases were washed successively with water (30 mL x 2) and saturated brine (20 mL). Dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The product was recrystallized from petroleum ether to give methyl 3-iodo-4-methoxybenzoate (37) (3.81 g). The yield was 88.4%.
References:
Atom Bioscience and Pharmaceutical Co., Ltd.;Shi, Dongfang;Fu, Changjin;Cheng, Xi CN106065010, 2016, A Location in patent:Paragraph 0134; 0135
121-98-2
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35387-93-0
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$16.00/1g
37470-46-5
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74-88-4
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35387-93-0
142 suppliers
$16.00/1g
4253-10-5
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35387-93-0
142 suppliers
$16.00/1g
15126-06-4
139 suppliers
$6.00/250mg
3337-66-4
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35387-93-0
142 suppliers
$16.00/1g