ChemicalBook CAS DataBase List Nalidixic acid

Nalidixic acid synthesis

9synthesis methods

Product Name:Nalidixic acid
CAS Number:389-08-2
Molecular formula:C12H12N2O3
Molecular Weight:232.24

Nalidixic acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthiridin-3- carboxylic acid (33.2.4), is synthesized by the following scheme. In the first stage, the reaction of 2-amino-6-methylpyridine and diethyl ethoxymethylenemalonate forms the substituted product (33.2.1), which when heated cyclizes to ethyl ester of 4-hydroxy -7-methyl-1,8-napthiridin-3-carboxylic acid (33.2.2). Hydrolyzing the resulting product with a base gives the corresponding acid (33.2.3). Alkylating this with ethyl iodide in the presence of potassium hydroxide gives nalidixic acid.

1824-81-3
487 suppliers
$8.00/25g

389-08-2
392 suppliers
$10.00/1g

[N-Ethyl-N-(6-methyl-2-pyridyl)amino]methylenemalonic acid diethyl ester

34748-19-1
0 suppliers
inquiry

389-08-2
392 suppliers
$10.00/1g

References

ethyl 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate

33331-59-8
7 suppliers
inquiry

389-08-2
392 suppliers
$10.00/1g

References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
0 suppliers
inquiry

389-08-2
392 suppliers
$10.00/1g

References

diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate

13250-95-8
31 suppliers
$32.30/1g

389-08-2
392 suppliers
$10.00/1g

References

Nalidixic acid Related Search:

Dihydromyrcenol Ethyl 2-(Chlorosulfonyl)acetate Glycine Methylparaben 2-Butanone oxime Methanol Acetonitrile Folic acid Citric acid

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.