Norepinephrine Impurity 7 synthesis
- Product Name:Norepinephrine Impurity 7
- CAS Number:2948-16-5
- Molecular formula:C8H7ClO3
- Molecular Weight:186.59
Yield:2948-16-5 82.62%
Reaction Conditions:
with triethylamine in dichloromethane at -5 - 0;Reagent/catalyst;
Steps:
1-2 Example 1:
Dissolve 10g catechol in 50ml dichloromethane, cool to -5°C-0°C, add 7.75g triethylamine, add dropwise the dichloromethane solution of chloroacetyl chloride (12.31g) under the condition of -5°C-0°C. Dissolve in 20ml of dichloromethane), after the addition is complete, keep the reaction for 2-4h, TLC (developing solvent: petroleum ether/ethyl acetate=5:1) shows that the reaction is complete, add 20ml of 1N hydrochloric acid aqueous solution and stirAfter 15 minutes, the liquid was separated, and the methylene chloride layer was spin-dried to obtain 14 g of an off-white solid intermediate I with a yield of 82.62%.
References:
CN113045415,2021,A Location in patent:Paragraph 0009-0012
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