ChemicalBook CAS DataBase List PAPAVERINE

PAPAVERINE synthesis

8synthesis methods

Product Name:PAPAVERINE
CAS Number:58-74-2
Molecular formula:C20H21NO4
Molecular Weight:339.39

Papaverine, 1-veratryl-6,7-dimethoxyisoquinolin (19.4.7), is synthesized from veratrol. Veratrol undergoes chloromethylation, forming 3,4-dimethoxybenzylchloride (19.4.1). Reacting this with potassium cyanide gives 3,4-dimethoxybenzylcyanide (19.4.2). The resulting 3,4-dimethoxybenzylcyanide undergoes reduction by hydrogen over Raney nickel, forming homoveratrylamine (19.4.3). At the same time 3,4-dimethoxybenzylcyanide (19.4.2) undergoes acidic hydrolysis giving 3,4-dimethoxyphenylacetic acid (19.4.4). The interaction of the resulting compounds brings to corresponding amide (19.4.5). The cyclization of this by Bischler–Napieralski method, using phosphorous oxychloride, gives 3,4-dihydropapaverine (19.4.6), which is dehydrated into the desired papverine when heated in tetraline at high temperatures.

6957-27-3 Synthesis

1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline

6957-27-3
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58-74-2
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$75.00/10mg

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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58-74-2
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$75.00/10mg

References

13074-31-2
56 suppliers
$265.00/1g

58-74-2
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$75.00/10mg

(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)-(3,4-dimethoxyphenyl)methanone

20345-69-1
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1000210-73-0
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7306-46-9
176 suppliers
$22.00/100mg

58-74-2
0 suppliers
$75.00/10mg

References

alpha-(3,4-dimethoxyphenyl)-6,7-dimethoxyisoquinoline-1-methanol

482-76-8
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58-74-2
0 suppliers
$75.00/10mg

References

PAPAVERINE Related Search:

Papaverine hydrochloride R-tetrahydropapaverine HCl Tetrahydropapaverine hydrochloride 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline 6,7-DIMETHOXYISOQUINOLINE

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