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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Pyrimethamine
58-14-0

Pyrimethamine synthesis

5synthesis methods
Pyrimethamine, 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine (33.1.60), is synthesized from 4-chlorobenzycyanide, which upon condensation with methyl ester of propionic acid in the presence of sodium methoxide gives the β-ketonitrile (33.1.58). Reacting this with ethyl orthoformate gives a methoxymethylene derivative (33.1.59), which upon heterocyclization in pyrimidine using guanidine as the binucleophile forms the desired pyrimethamine (33.1.60).

4-Chlorobenzyl cyanide

140-53-4
504 suppliers
$13.00/25g

Pyrimethamine

58-14-0
486 suppliers
$5.00/100mg

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5-(4-chlorophenyl)pyrimidine-2,4-diamine

17039-14-4
8 suppliers
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4433-63-0 Synthesis
Ethylboronic acid

4433-63-0
292 suppliers
$5.00/1g

Pyrimethamine

58-14-0
486 suppliers
$5.00/100mg

References
1679-18-1 Synthesis
4-Chlorophenylboronic acid

1679-18-1
622 suppliers
$10.00/1g

514854-13-8 Synthesis
6-Ethyl-5-iodopyriMidine-2,4-diaMine

514854-13-8
45 suppliers
$36.00/100mg

Pyrimethamine

58-14-0
486 suppliers
$5.00/100mg

References
62538-21-0 Synthesis
2-(4-Chlorophenyl)-2-cyanoacetaldehyde

62538-21-0
77 suppliers
$33.93/250mgs:

Pyrimethamine

58-14-0
486 suppliers
$5.00/100mg

References
3-azidopyrimethamine

95458-40-5
1 suppliers
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Pyrimethamine

58-14-0
486 suppliers
$5.00/100mg

References

Pyrimethamine Related Search:

Uracil Ethanol Ethyl acetate L-1-Phenylethylamine tert-Butylchlorodiphenylsilane Pyrimidine Triethylamine Sulfadiazine Phenethyl chloride Triphenylmethyl Chloride