Safrole synthesis
- Product Name:Safrole
- CAS Number:94-59-7
- Molecular formula:C10H10O2
- Molecular Weight:162.19
274-09-9
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$5.00/5g
107-18-6
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$24.60/100ml
94-59-7
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$29.00/10mg
120-58-1
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$65.00/1mg
Yield:94-59-7 80%
Reaction Conditions:
with Nafion-H resin at 20;Friedel-Crafts Alkylation;
Steps:
General procedure
Nafion-H (14.65 g, 10 % wt. % based on the 1,2-methylene-dioxybenzene was used) was added to the mixture of 1,2-methylenedioxybenzene (146.54 g, 1.2 mol) and allyl alcohol (2.33 g, 0.04 mol) and stirred at room temperature until the allyl alcohol is disappeared. The Nafion-H catalyst was filtered off. Excess 1,2-methylenedioxybenzene was removed under reduced pressure. The crude product was vacuum distilled, 5.19 g of safrole, boiling at 120-130 °C (10-15 mm Hg), was obtained. Colourless and typically smelling oil. Total yield (from the allyl alcohol), 80 % of theory.
References:
Ou, Wenhua;Huang, Hong [Asian Journal of Chemistry,2015,vol. 27,# 3,p. 1175 - 1176]
14268-66-7
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762-72-1
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$10.00/1g
94-59-7
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$29.00/10mg