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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Sitagliptin Defuoro IMpurity 3
851307-12-5

Sitagliptin Defuoro IMpurity 3 synthesis

4synthesis methods
81228-09-3 Synthesis
2,4-Difluorophenylacetic acid

81228-09-3
274 suppliers
$12.00/2 g

Sitagliptin Defuoro IMpurity 3

851307-12-5
74 suppliers
$172.00/100mg

-

Yield:-

Steps:

Multi-step reaction with 8 steps
1: (COCl)2; DMF / CH2Cl2
2: 2,4,6-collidine
3: 81 percent / 4 h / Heating
4: 87 percent / AcOH / methanol / 2 h / 40 °C
5: 42 percent / H2 / PtO2 / tetrahydrofuran; methanol / 4654.46 Torr
6: AcOH / Pearlman's catalyst / methanol; H2O
7: Et3N / CH2Cl2
8: 87 percent / aq. LiOH / tetrahydrofuran

References:

Kim, Dooseop;Kowalchick, Jennifer E.;Edmondson, Scott D.;Mastracchio, Anthony;Xu, Jinyou;Eiermann, George J.;Leiting, Barbara;Wu, Joseph K.;Pryor, KellyAnn D.;Patel, Reshma A.;He, Huaibing;Lyons, Kathryn A.;Thornberry, Nancy A.;Weber, Ann E. [Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,# 12,p. 3373 - 3377]

4-(2,4-DIFLUORO-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER

942475-04-9
9 suppliers
inquiry

Sitagliptin Defuoro IMpurity 3

851307-12-5
74 suppliers
$172.00/100mg

References
Benzenebutanoic acid, β-[[(1S)-2-amino-2-oxo-1-phenylethyl]amino]-2,4-difluoro-, methyl ester, (βR)-

945261-73-4
0 suppliers
inquiry

Sitagliptin Defuoro IMpurity 3

851307-12-5
74 suppliers
$172.00/100mg

References
141060-00-6 Synthesis
2,4-Difluorophenyl acetic acid

141060-00-6
21 suppliers
$15.00/1g

Sitagliptin Defuoro IMpurity 3

851307-12-5
74 suppliers
$172.00/100mg

References

Sitagliptin Defuoro IMpurity 3 Related Search:

2,4,5-Trifluorobenzaldehyde Sitagliptin phosphate monohydrate (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Sitagliptin N-Boc IMpurity 2,4,5-Trifluorophenylacetic acid 3,4-Difluorophenylacetic acid Ethyl trifluoroacetate 2,4-Difluorophenylacetic acid