产品货号:jlcR6987
英文名称:C12orf23
中文名称第:12号染色体开放阅读框23抗体
别名:C12orf23; Chromosome 12 open reading frame 23; CL023_HUMAN; MGC17943; UPF0444 transmembrane protein C12orf23.
研究领域:心血管细胞生物免疫学神经生物学细胞周期蛋白
抗体来源:Rabbit
克隆类型:Polyclonal
交叉反应: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用:ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量:12kDa
细胞定位:细胞膜
性状:Lyophilized or Liquid
浓度:1mg/ml
免疫原:KLH conjugated synthetic peptide derived from human C12orf23:68-116/116
亚型:IgG
纯化方法:affinity purified by Protein A
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed:PubMed
产品介绍background:
C12orf23 (chromosome 12 open reading frame 23), also known as FLJ11721, FLJ13959 or MGC17943, is a 116 amino acid multi-pass membrane protein belonging to the UPF0444 family. C12orf23 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).
Similarity:
Belongs to the UPF0444 family.
SWISS:
Q8WUH6
Gene ID:
90488
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
