【Molecular Wt.】20-30kDa

【Description】Members of the tumor necrosis factor (TNF) receptor superfamily interact with signaling molecules of the TNF receptor-associated factor (TRAF) family to activate the NF?B and JNK pathways. RANK (receptor activator of NF?B) is a member of the TNFR family identified on dendritic cells. This type I membrane receptor is expressed in a broad range of tissues. The C-terminus of RANK is required for RANK to bind TRAF2, 5 and 6, and it is also necessary for stimulating NF?B activation. The ligand for this receptor, RANKL (also designated TRANCE, OPGL or ODF), is a type II transmembrane protein expressed primarily in lymphoid tissues and T cell lines. RANKL appears to be an important regulator of T cells and osteoclasts.

【Species Reactivity】Human;Mouse;Rat

【Tested applications】WB;IP;IF;IHC-P

【Antibody type】Goat polyclonal Antibody

【Immunogen】peptide

【Positive control】BYDP, LNCaP

【Conjugate】Non-conjugated

【Alternative names】CD254 antibody
hRANKL2 antibody
ODF antibody
OPGL antibody
OPTB2 antibody
Osteoclast differentiation factor antibody
Osteoprotegerin ligand antibody
RANKL antibody
Receptor activator of nuclear factor kappa B ligand antibody
Receptor activator of nuclear factor kappa-B ligand antibody
sOdf antibody
TNF related activation induced cytokine antibody
TNF-related activation-induced cytokine antibody
TNF11_HUMAN antibody
TNFSF 11 antibody
Tnfsf11 antibody
TRANCE antibody
Tumor necrosis factor (ligand) superfamily member 11 antibody
Tumor necrosis factor ligand superfamily member 11 antibody
Tumor necrosis factor ligand superfamily member 11, soluble form antibody

【Form】Liquid

【Stroage】Store at +4℃

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Immunogen affinity purified

【Subcellular location】Cytoplasm, Secreted, Cell membrane

【Background References】1. Garcia, V.G., et al. 2011. Treatment of experimental periodontal disease with antimicrobial photodynamic therapy in nicotine-modified rats. J. Clin.Periodontol. 38: 1106-1114.
2. Claudino, M., et al. 2012. Spontaneous periodontitis development in diabetic rats involves an unrestricted expression of inflammatory cytokines and tissue destructive factors in the absence of major changes in commensal oral microbiota. Exp. Diabetes Res. 2012: 356841.

【DatasheetURL】http://www.huabio.com/upload/RT1529.pdf

【Uniprot ID】O14788

【Raised in】Goat

【Clone No.】