Facile, catalyst-free cascade synthesis of sulfonyl guanidines via carbodiimide coupling with amines†,10.1039/C8CC08564A

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Facile, catalyst-free cascade synthesis of sulfonyl guanidines via carbodiimide coupling with amines†

Debojit Hazarika,Arun Jyoti Borah,Prodeep Phukan

Chemical Communications Pub Date : 01/14/2019 00:00:00 , DOI:10.1039/C8CC08564A

Abstract

An expeditious catalyst-free cascade coupling of N,N-dibromoarylsulfonamides with isonitriles and amines via carbodiimide intermediates has been developed. The protocol represents an elegant pathway for sulfonyl guanidines at room temperature within a short time with high yields and wide substrate scope. The carbodiimide intermediate could also be isolated in an appreciable yield.