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Rhodium(iii)-catalyzed cascade C–H functionalization/annulation of sulfoximines with iodonium ylides for the synthesis of cyclohexanone-1,2-benzothiazines†
Lu Chen,Zhichao Wang,Yangyang Wang,Liqiang Hao,Xiaobo Xu,Gaorong Wu,Yafei Ji
Organic & Biomolecular Chemistry Pub Date : 12/24/2021 00:00:00 , DOI:10.1039/D1OB02110A
Abstract

A highly efficient Rh(III)-catalyzed cascade C–H activation/annulation of sulfoximines with iodonium ylides under metal-oxidant-free conditions has been reported. The fused cyclohexanone-1,2-benzothiazine scaffold is readily achieved with a one-pot process in this reaction. This protocol exhibits good functional group tolerance and moderate to excellent yields. Additionally, the olefination of the target product illustrates the promising usefulness of this strategy.

Graphical abstract: Rhodium(iii)-catalyzed cascade C–H functionalization/annulation of sulfoximines with iodonium ylides for the synthesis of cyclohexanone-1,2-benzothiazines
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