Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone†
Sau Hing Chan,Albert S. C. Chan,Fuk Yee Kwong
Organic & Biomolecular Chemistry Pub Date : 09/16/2011 00:00:00 , DOI:10.1039/C1OB06191G
Abstract

A Michael-type reaction of β,γ-unsaturated α-keto ester and α-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47–94% yields with 68–96% ee.

Graphical abstract: Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone