Vancomycin
万古霉素(Vancomycin)
CAS: 1404-90-6
化学式: C66H75Cl2N9O24
| 中文名 | 万古霉素 |
| 英文名 | Vancomycin |
| 别名 | 万古霉素 万古霉素碱 万古霉素 万古霉素碱 |
| 英文别名 | Vancoled HSDB 3262 Vancomycin VANCOMYCIN UNII-6Q205EH1VU Vancomycin Base Vancomycinum [INN-Latin] vancomycin hcl vancocin Vancomycine [INN-French] Vancomicina [INN-Spanish] |
| CAS | 1404-90-6 |
| EINECS | 215-772-6 |
| 化学式 | C66H75Cl2N9O24 |
| 分子量 | 1449.25 |
| InChI | InChI=1/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1 |
| 密度 | 1.2882 (rough estimate) |
| 熔点 | >274°C (dec.) |
| 溶解度 | DMSO (微溶) |
| 折射率 | 1.7350 (estimate) |
| 酸度系数 | pKa 2.18±0.08(H2Ot = 25.0±0.1I = 0.2 (NaCl)N2 atmosphere) (Uncertain);7.75±0.02(H2Ot = 25.0±0.1I = 0 |
| 存储条件 | 2-8°C |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | Off-White |
| 体外研究 | Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci . |
| 体内研究 | Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment. |
| 上游原料 | 万古霉素杂质 |
| 下游产品 | 乙酰基-赖氨酰(乙酰基)-D-丙氨酰-D-丙氨酸 |
| 参考资料 展开查看 | 1. 崔若宇, 李美娜, 方婷,等. 纸色谱法实现对丙氨酸快速手性分离的研究[J]. 化学教育, 2018, 039(004):22-24. 2. 潘文娟,林家富,王小桃,郭义东,褚以文,刘超兰.西藏湖泊放线菌的分离鉴定及抗菌活性测定[J].生物技术通报,2020,36(07):97-103. 3. Zhang, Fangxing, et al. "The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice." Frontiers in microbiology 11 (2020): 2126.http://doi.org/10.3389/fmicb.2020.557342 4. [IF=9.229] Mimi Wan et al."In Situ Growth of Mesoporous Silica with Drugs on Titanium Surface and Its Biomedical Applications."Acs Appl Mater Inter. 2017;9(22):18609–18618 5. [IF=3.659] Rong Qian et al."In vitro and in vivo bactericidal activity of Tinospora sagittata (Oliv.) Gagnep. var. craveniana (S.Y.Hu) Lo and its main effective component, palmatine, against porcine Helicobacter pylori."Bmc Complem Altern M. 2016 Dec;16(1):1-8 6. [IF=10.588] Fangchao Yin et al."A portable digital optical kanamycin sensor developed by surface-anchored liquid crystal droplets."J Hazard Mater. 2021 Oct;420:126601 7. [IF=7.514] Ximo Wang et al."A novel SERS sensor for the ultrasensitive detection of kanamycin based on a Zn-doped carbon quantum dot catalytic switch controlled by nucleic acid aptamer and size-controlled gold nanorods."Food Chem. 2021 Nov;362:130261 8. [IF=7.328] Tianjie Chen et al."Construction and performance evaluation of a sustained release implant material polyetheretherketone with antibacterial properties."Mat Sci Eng C-Mater. 2021 Jul;126:112109 9. [IF=4.235] Zhang Fangxing et al."The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice."Front Microbiol. 2020 Oct;0:2126 10. [IF=2.461] Huang Xue-Jiao et al."The Antibacterial Properties of 4, 8, 4′, 8′-Tetramethoxy (1,1′-biphenanthrene) -2,7,2′,7′-Tetrol from Fibrous Roots of Bletilla striata."Indian J Microbiol. 2021 Jun;61(2):195-202 11. [IF=2.281] Zhiqiang Zhang et al."Contribution of the colicin receptor CirA to biofilm formation, antibotic resistance, and pathogenicity of Salmonella Enteritidis."J Basic Microb. 2020 Jan;60(1):72-81 12. [IF=6.057] Supan Cheng et al."Liquid crystal-based sensitive and selective detection of uric acid and uricase in body fluids."Talanta. 2022 Jul;244:123455 |
供应商列表
主打产品现货供应
产品名: 万古霉素 去供应商网站查看 询盘CAS: 1404-90-6
产地: 上海
包装: 250mg,1g,5g,25g,100g,1ml,250mg,1g,5g,25g,100g,1ml
规格: V871983,V871983,V871983,V871983,V871983,V793720,V871983,V871983,V871983,V871983,V871983,V793720
价格: 149,359,1210,3142,7110,205,149,359,1210,3142,7110,205
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
主打产品提供多种规格现货供应
产品名: Vancomycin 去供应商网站查看 询盘CAS: 1404-90-6
产地: 美国
包装: 10 mM * 1 mL;25 mg;50 mg;100 mg;1 g
规格: HY-B0671
价格: 询价
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.39%
产品名: 万古霉素 去供应商网站查看 询盘
CAS: 1404-90-6
产地: 上海
包装: 250mg,1g,5g,25g,100g,1ml,250mg,1g,5g,25g,100g,1ml
规格: V871983,V871983,V871983,V871983,V871983,V793720,V871983,V871983,V871983,V871983,V871983,V793720
价格: 149,359,1210,3142,7110,205,149,359,1210,3142,7110,205
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
CAS: 1404-90-6
产地: 上海
包装: 250mg,1g,5g,25g,100g,1ml,250mg,1g,5g,25g,100g,1ml
规格: V871983,V871983,V871983,V871983,V871983,V793720,V871983,V871983,V871983,V871983,V871983,V793720
价格: 149,359,1210,3142,7110,205,149,359,1210,3142,7110,205
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
产品名: Vancomycin 去供应商网站查看 询盘
CAS: 1404-90-6
产地: 美国
包装: 10 mM * 1 mL;25 mg;50 mg;100 mg;1 g
规格: HY-B0671
价格: 询价
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.39%
CAS: 1404-90-6
产地: 美国
包装: 10 mM * 1 mL;25 mg;50 mg;100 mg;1 g
规格: HY-B0671
价格: 询价
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.39%
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