| 中文名 | 松胞菌素B
|
| 英文名 | Cytochalasin B
|
| 别名 | 松胞素B
松胞菌素B
细胞松驰素B
细胞松弛素B
细胞分裂抑素B
细胞松弛素 B
细胞松弛素 B 来源于长蠕孢菌
CYTOCHALASIN B 细胞松弛素B
细胞松弛素 B 来源于DRECHSLERA DEMATIOIDEA
|
| 英文别名 | Phomin
HSDB 3479
CCRIS 9284
BRN 1096207
cytochalasin
Cytochalasin B
ec[2,3-d]isoindole-2,18(5h)-dione
Cytochalasin B, froM Drechslera deMatoidea
CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM
CytochalasinB from Drechslera dematioidea,Phomin
Cytochalasin B from Helminthosporium dematioideum
7,20-Dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-(14)cytochalas-6(12),13,21-trien-23-one
7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-
Cytochalasin B (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
(E,E)-16-BENZYL-6,7,8,9,10,12A,13,14,15,15A,16,17-DODECAHYDRO-5,13-DIHYDROXY-9,15-DIMETHYL-14-METHYLENE-2H-OXACYCLOTETRADE[2,3-D]ISOINDOLE-2,18(5H)-DIONE
(3E,5S,9R,11E,12aS,13S,15S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
(E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione
2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E)-(5S,9R,12aS,13S,15S,15aS,16aS,18aS)-
2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
(3E,5S,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-
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| CAS | 14930-96-2
|
| EINECS | 239-000-2 |
| 化学式 | C29H37NO5
|
| 分子量 | 479.61 |
| InChI | InChI=1/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22+,23+,24?,26?,27-,29-/m1/s1 |
| InChIKey | UXVDBQLLXVKPRS-UZBFCAAUSA-N |
| 密度 | 1.1490 (rough estimate) |
| 熔点 | 218-223 °C |
| 沸点 | 577.96°C (rough estimate) |
| 闪点 | 85℃ |
| 蒸汽压 | 4.98E-23mmHg at 25°C |
| 溶解度 | 乙醇: 20mg/ml |
| 折射率 | 1.6290 (estimate) |
| 酸度系数 | 13.60±0.70(Predicted) |
| 存储条件 | -20°C |
| 稳定性 | 从提供的购买之日起稳定2年。DMSO中的溶液可以在-20 °C下储存长达1个月。 |
| 外观 | 粉末 |
| 颜色 | white |
| Merck | 13,2819 |
| BRN | 1096207 |
| 体外研究 | Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, inhibits the enlongation and shortening of actin filaments, with K d s of 2.2 nM and 1.4 nM for F-actin in the presence of MgCl 2 (2 mM) or MgCl 2 (2 mM) plus KCl, respectively. Cytochalasin B (0.1-10 μM) shows inhibitory effect on multiple murine cancer cell lines, with IC 50 s of 2.56 μM (M109c), 10.46 μM (B16BL6), 105.5 μM (P388/ADR), 51.9 μM (P388/S) and IC 80 s of 12.23 μM (M109c), 44.86 μM (B16BL6), 188.4 μM (P388/ADR), 84.1 μM (P388/S) after treatment for 3 h, with IC 50 s of 0.25 μM (M109c), 0.37 μM (B16F10), 0.87 μM (B16BL6), and IC 80 s of 0.75 μM (M109c), 1.21 μM (B16F10), 10.41 μM (B16BL6) after treatment for 4 days. Cytochalasin B (6 μM) increases the myofibrillar fragmentation index (MFI), which is attributed to the intensely breaking of myofibrillar proteins into short segments. Cytochalasin B also accelerates the disruption of actin filaments. In addition, Cytochalasin B accelerates the transformation from F-actin to G-actin, lowering the content of F-actin and significantly increasing G-actin bands during postmortem conditioning. |
| 体内研究 | Cytochalasin B (10, 25, 50 mg/kg, i.p.) dose-dependently increases the life expectancy of Balb/c mice bearing with P388/ADR leukemias. Cytochalasin B at 50 mg/kg produces 10 % long-term survival in the multidrug resistant P388/ADR cohort, and 40 % long-term survival in the drug sensitive P388/S cohort. |
| 危险品标志 | T+ - 极高毒性物品
T - 有毒物品
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| 风险术语 | R26/27/28 - 吸入、皮肤接触及吞食有极高毒性。
R63 - 可能有对胎儿造成伤害的危险。
R23/24/25 - 吸入、皮肤接触及吞食有毒。
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| 安全术语 | S28 - 不慎与皮肤接触后，立即用大量肥皂水冲洗。
S36/37 - 穿戴适当的防护服和手套。
S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
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| 危险品运输编号 | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | RO0205000 |
| FLUKA BRAND F CODES | 10 |
| 海关编号 | 29349990 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| 下游产品 | 细胞松驰素 A |
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