氧化低密度脂蛋白

中文名	氧化低密度脂蛋白
英文名	Oxidized LDL
别名	氧化低密度脂蛋白人氧化低密度脂蛋白
存储条件	2-8 ℃, 1 month
参考资料展开查看	1. Jia, QingLing, et al. "Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264. 7 macrophage-derived foam cells." European journal of pharmacology 865 (2019): 172748.http://doi.org/10.1016/j.ejphar.2019.172748 2. [IF=2.638] Hu Zhang et al."miR-758 mediates oxLDL-dependent vascular endothelial cell damage by suppressing the succinate receptor SUCNR1."Gene. 2018 Jul;663:1 3. [IF=2.1] Shanshan Li et al."Quercetin protects against ox‑LDL‑induced injury via regulation of ABCAl, LXR‑α and PCSK9 in RAW264.7 macrophages."Mol Med Rep. 2018 Jul;18(1):799-806 4. [IF=2.1] Lin Sun et al."Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model."Mol Med Rep. 2018 Jan;17(1):257-263 5. [IF=9.776] Huijuan Zhang et al."Thrombus-targeted nanoparticles for thrombin-triggered thrombolysis and local inflammatory microenvironment regulation."J Control Release. 2021 Nov;339:195 6. [IF=7.46] Shufen Li et al."A lipid droplets specific probe for imaging of atherosclerosis and fibrocalcific bicuspid aortic valves."Sensor Actuat B-Chem. 2021 Nov;346:130458 7. [IF=6.331] Shufen Li et al."Turn-on fluorescent probe for lipid droplet specific imaging of fatty liver and atherosclerosis."J Mater Chem B. 2021 May;9(19):4050-4055 8. [IF=5.076] Dou Fangfang et al."PPARα Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model."Oxid Med Cell Longev. 2021;2021:2045259 9. [IF=4.556] Hui Cao et al."Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells."Int J Mol Sci. 2019 Jan;20(23):6093 10. [IF=4.192] Fengming Liu et al."Treatment of Peroxidase Derived from Foxtail Millet Bran Attenuates Atherosclerosis by Inhibition of CD36 and STAT3 in Vitro and in Vivo."J Agr Food Chem. 2020;68(5):1276–1285 11. [IF=3.375] Fangfang Dou et al."Anti-atherosclerotic effects of LXRα agonist through induced conversion of M1 macrophage to M2."Am J Transl Res. 2019; 11(6): 3825–3840 12. [IF=3.263] QingLing Jia et al."Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells."Eur J Pharmacol. 2019 Dec;865:172748 13. [IF=1.813] Ma Qianqian et al."Protective Effect of Shenqi Maixintong Capsule against ox-LDL-Induced Injury in RAW264.7 Macrophages."Evid-Based Compl Alt. 2020;2020:6708152 14. [IF=15.881] Ziyu Wu et al."Carrier-Free Trehalose-Based Nanomotors Targeting Macrophages in Inflammatory Plaque for Treatment of Atherosclerosis."Acs Nano. 2022;XXXX(XXX):XXX-XXX 15. [IF=4.098] Shufen Li et al."An intelligent probe with dual-emission in water and oil for lipid droplet specific imaging in human fibrocalcific aortic valvular leaflet."Spectrochim Acta A. 2022 Apr;271:120895 16. [IF=5.279] Shuhua Shan et al."Bowman-Birk Major Type Trypsin Inhibitor Derived from Foxtail Millet Bran Attenuate Atherosclerosis via Remodeling Gut Microbiota in ApoE–/– Mice."J Agr Food Chem. 2022;XXXX(XXX):XXX-XXX 17. [IF=13.281] Ziyu Wu et al."Multi-Pathway Microenvironment Regulation for Atherosclerosis Therapy Based on Beta-Cyclodextrin/L-Arginine/Au Nanomotors with Dual-Mode Propulsion."Small. 2021 Dec 16 18. [IF=4.616] Jingruo Chen et al."A lipid droplet-specific fluorescence probe for atherosclerotic plaque imaging."ANALYST. 2022 May;:

氧化低密度脂蛋白 - 简介

氧化低密度脂蛋白（Oxidized LDL）是一种具有氧化性的低密度脂蛋白（LDL）分子。以下是有关氧化LDL的性质，用途，制法和安全信息的介绍：

性质：
- 氧化LDL是一种由LDL分子经氧化反应产生的衍生物。它的氧化状态使其具有一些特殊的性质。
- 氧化LDL分子通常会变得更加不稳定，容易发生结构改变，并且容易被巨噬细胞和其他细胞识别和吞噬。
- 氧化LDL可能导致炎症反应和氧化应激，从而对细胞和组织产生不良影响。

用途：
- 氧化LDL在研究和临床诊断中被广泛应用。它可以作为评估动脉粥样硬化风险的生物标志物之一，因为氧化LDL与心血管病的发生和发展有关。
- 某些研究还探索了氧化LDL在其他疾病如癌症、糖尿病等中的潜在作用。

制法：
- 通常，氧化LDL的制备是通过将LDL暴露在氧化剂如Cu2+、Fe2+等的存在下，利用氧化反应使其发生氧化。
- 这种方法可以模拟炎症和氧化应激等条件下LDL的氧化过程。

安全信息：
- 氧化LDL是一种具有氧化性的物质，在处理和存储过程中需要采取防护措施，避免对人体和环境造成危害。
- 研究中使用的氧化LDL需要遵守相关实验室安全操作规范，并严格控制其接触和使用的量。

最后更新：2024-04-09 20:49:11