落妇新苷
落妇新苷((2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside)
CAS: 29838-67-3
化学式: C21H22O11
| 中文名 | 落妇新苷 |
| 英文名 | (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside |
| 别名 | 落新妇苷 落妇新苷 落新妇苷(分析标准品) 落新妇苷, 来源于土茯苓 紫杉叶3-O鼠李甲基酸酯 ASTILBIN 落新妇苷 标准品 落新妇苷(紫杉叶3-O鼠李甲基酸酯 花旗松素-3-O-Α-L-吡喃鼠李糖苷) 紫杉叶3-O鼠李甲基酸酯,花旗松素-3-O-Α-L-吡喃鼠李糖苷 落新妇苷(紫杉叶3-O鼠李甲基酸酯,花旗松素-3-O-Α-L-吡喃鼠李糖苷) |
| 英文别名 | astilbin Astilbin Taxifolin 3-rhaMnoside Taxifolin 3-o-rhamnoside Dihydroquercetin 3-rhamnoside Astilbin Taxifolin 3-O-rhaMnoside Astilbin froM Engelhardtia roxburghiana (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chroMen-3-yl 6-deoxy-alpha-L-Mannopyranoside (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside (2R-trans)-3-((6-Deoxy-alpha-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2R,3R)- 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2R-trans)- |
| CAS | 29838-67-3 |
| EINECS | 694-695-3 |
| 化学式 | C21H22O11 |
| 分子量 | 450.4 |
| InChI | InChI=1/C21H22O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-26,28-29H,1H3/t7-,15-,17+,18+,19+,20-,21-/m0/s1 |
| 密度 | 1.74 |
| 熔点 | 180 °C (decomp) |
| 沸点 | 801.1±65.0 °C(Predicted) |
| 闪点 | 282.9°C |
| 蒸汽压 | 4.42E-27mmHg at 25°C |
| 溶解度 | H2O: 可溶物1mg/mL，澄清，无色 |
| 折射率 | 1.748 |
| 酸度系数 | 7.34±0.60(Predicted) |
| 存储条件 | Sealed in dry,2-8°C |
| 外观 | 无色晶体 |
| 物化性质 | 白色结晶粉末，易溶于沸水，几乎不溶于乙醚，来源于土茯苓、菝葜，黄杞Engelhardtia roxburghiana Wall.红绒毛羊蹄甲。 |
| MDL号 | MFCD20274680 |
| 体外研究 | Astilbin is a common dietary flavonoid that can be found in various kinds of herbs and foods such as Smilax Glabra , Sarcandra glabra , grape and red wine. Astilbin markedly inhibits cisplatin-induced cell apoptosis and recovers cell growth. Astilbin significantly decreases reactive oxygen species (ROS) accumulation and alleviates ROS-induced activation of p53, MAPKs and AKT signaling cascades, which in turn attenuates cisplatin-induced HEK-293 cell apoptosis. Astilbin effectively enhances NRF2 activation and transcription of its targeting antioxidant genes to reduce ROS accumulation in cisplatin-induced HEK-293 cells. Astilbin obviously suppresses tumor necrosis factor alpha (TNF-α) expression and NF-κB activation, and also inhibits the expression of induced nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). To measure the effects of Astilbin on the growth of CDDP-treated renal cells, HEK-293 cells are treated with CDDP (100 μM) and/or Astilbin (200 μM). Astilbin treatment significantly improvescell growth in CDDP-induced HEK-293 cells. |
| 体内研究 | To explore whether Astilbin improves CDDP-induced nephrotoxicity in vivo, an acute cisplatin nephrotoxic mouse model is established. Single injection of CDDP with 8 mg/kg dose results in notable weight loss compared with control group. However, the phenomenon is significantly alleviated by Astilbin at dose of 50 mg/kg. The mice fed Astilbin alone do not show any obvious alteration in body weight. Similarly, serum creatinine (SCr) and blood urea nitrogen (BUN) are higher in CDDP-treated mice than in control group. Treatment with Astilbin also decreases SCr and BUN levels. To examine the protective effect of Astilbin on CDDP-induced renal histopathological damage, the mouse kidney sections are stained with H&E. The mice in control group and Astilbin treated group have normal kidney morphology, while kidneys in CDDP group show severe damage with tubular degeneration, necrosis and cystic dilatation of the tubules with focal hemorrhages. Administration of Astilbin mitigated kidney injury, resulting in lower histopathological score compared to CDDP group. The apoptosis of renal cells is also detected using TUNEL staining to determine whether Astilbin treatment decreased renal cell apoptosis in CDDP-induced acute nephrotoxic mice. |
| 危险品标志 | N - 危害环境的物品 |
| 风险术语 | 50 - 对水生生物有极高毒性。 |
| 安全术语 | 61 - 避免释放至环境中。参考特别说明/安全数据说明书。 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| 海关编号 | 29389090 |
| 参考资料 展开查看 | 1. 姜宣羽, 王思为, 楼丽君,等. 土茯苓活性分子落新妇苷抗顺铂诱导的人肾小管上皮细胞凋亡作用研究[J]. 浙江中西医结合杂志, 2018, 28(09):735-738. 2. 王思为, 张峰, 郑晓燕,等. 土茯苓活性分子落新妇苷联合顺铂对人肺癌A549细胞凋亡的影响[J]. 中药材, 2017(12). 3. 赵瑞芝, 史长灿, 刘丽娟,等. 芍苓消银缓释片Beagle犬体内药物动力学评价[J]. 中国医院药学杂志, 2017, 11(v.37):17-19. 4. 黄慧辉, 张小燕, 沈娟,等. 菝葜抗炎有效部位群在大鼠肠外翻试验中的吸收特性考察[J]. 中国实验方剂学杂志, 2016, v.22(08):96-99. 5. 徐萍,张淼,徐玉彬,毛旭南,张培建.落新妇苷预处理对大鼠肝脏缺血再灌注损伤和Bcl-2、Bax表达的影响[J].中国药师,2016,19(11):2055-2058. 6. 王银洁, 赵瑞芝, 卢传坚. 银屑灵与土茯苓中落新妇苷大鼠体内的药代动力学比较[J]. 中国中药杂志, 2012, 37(12):1859-1861. 7. 邹静 陈慧 彭懿 等. HPLC法同时测定加味二妙颗粒中7种成分及指纹图谱建立[J]. 中成药 2018 v.40(02):99-104. 8. 冯丽敏 赵瑞芝 卢传坚. HPLC同时测定芍苓消银片中芍药苷 落新妇苷 绿原酸 迷迭香酸和甘草酸的含量[J]. 中国现代应用药学 2014 031(009):1097-1101. 9. 潘馨 衷林清 周楚楚 等. HPLC同时测定草珊瑚中9个有效成分的含量[J]. 药物分析杂志 2017 037(007):1207-1214. 10. 杨俊杰, 黄紫炎, 李林,等. 土茯苓产地加工与炮制一体化工艺优选[J]. 时珍国医国药, 2018, 29(09):2165-2168. 11. 杨俊杰,张艳玲,王峥涛,陆兔林.土茯苓产地加工过程中去皮的合理性分析[J].中国实验方剂学杂志,2017,23(03):1-5. 12. 赵瑞芝,王银洁,冯丽敏,卢传坚.大鼠口服芍苓消银片后血液中芍药苷、落新妇苷、迷迭香酸、异嗪皮啶、甘草苷的药物动力学研究[J].中国中药杂志,2014,39(13):2559-2563. 13. 冯丽敏, 赵瑞芝, 王银洁,等. 正交设计法优选银屑灵片中肿节风有效成分的提取工艺[J]. 时珍国医国药, 2011(08):1860-1861. 14. 王梦雪,戴寒鹏,李金明,苏娅,韩欣然,李丽.土茯苓抑制CYP3A4酶活性的研究[J].长春师范大学学报,2020,39(08):60-63. 15. Sun, Xiaoqi, et al. "Caspase-dependent mitochondrial apoptotic pathway is involved in astilbin-mediated cytotoxicity in breast carcinoma cells." Oncology reports 40.4 (2018): 2278-2286.http://doi.org/10.3892/or.2018.6602 16. Yang, Mao, et al. "Astilbin influences the progression of osteoarthritis in rats by down-regulation of PGE-2 expression via the NF-κB pathway." Annals of Translational Medicine 8.12 (2020).http://dx.doi.org/10.21037%2Fatm-20-4485 17. Wang, Si-wei, et al. "Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation." Food and chemical toxicology 114 (2018): 227-236.http://doi.org/10.1016/j.fct.2018.02.041 18. Hui Bi, Zhen Sun, Qiubo Chu, Lanzhou Li, Xin Guan, Yulin Zhou & Zhiwen Li (2019) Analgesic effects of astilbin partially via calcium channels through regulation on CaMKII, Food and Agricultural Immunology, 30:1, 309-319, DOI: 10.1080/09540105.2019.1580677 19. Duan, Qianni, et al. "Antiviral effect of Chinese herbal prescription JieZe-1 on adhesion and penetration of VK2/E6E7 with herpes simplex viruses type 2." Journal of ethnopharmacology 249 (2020): 112405.http://doi.org/10.1016/j.jep.2019.112405 20. [IF=4.36] Yueqin Cai et al."Medicinal effect and its JP2/RyR2-based mechanism of Smilax glabra flavonoids on angiotensin II-induced hypertrophy model of cardiomyocytes."J Ethnopharmacol. 2015 Jul;169:435 21. [IF=3.906] Xiaoqi Sun et al."Caspase-dependent mitochondrial apoptotic pathway is involved in astilbin-mediated cytotoxicity in breast carcinoma cells."Oncol Rep. 2018 Oct;40(4):2278-2286 22. [IF=3.775] Si-wei Wang et al."Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation."Food Chem Toxicol. 2018 Apr;114:227 23. [IF=2.398] Hui Bi et al."Analgesic effects of astilbin partially via calcium channels through regulation on CaMKII."Food Agr Immunol. 2019;30(1):309-319 24. [IF=6.529] Xue Chen et al."Dendrobium officinalis six nostrum ameliorates urate under-excretion and protects renal dysfunction in lipid emulsion-induced hyperuricemic rats."Biomed Pharmacother. 2020 Dec;132:110765 25. [IF=4.225] Wen Xianghui et al."Qu-Zhuo-Tong-Bi Decoction Alleviates Gouty Arthritis by Regulating Butyrate-Producing Bacteria in Mice."Front Pharmacol. 2021 Feb;11:2508 26. [IF=3.69] Qianni Duan et al."Antiviral effect of Chinese herbal prescription JieZe-1 on adhesion and penetration of VK2/E6E7 with herpes simplex viruses type 2."J Ethnopharmacol. 2020 Mar;249:112405 27. [IF=3.297] Mao Yang et al."Astilbin influences the progression of osteoarthritis in rats by down-regulation of PGE-2 expression via the NF-κB pathway."Ann Transl Med. 2020 Jun; 8(12): 766 28. [IF=1.216] Han Yan et al."Studies on the Anti-Gouty Arthritis and Anti-hyperuricemia Properties of Astilbin in Animal Models."Open Chem. 2020 Jan;18(1):207-214 29. [IF=5.396] Tingwei Wang et al."Astilbin from Smilax glabra Roxb. alleviates high-fat diet-induced metabolic dysfunction."Food Funct. 2022 Apr;: |
落妇新苷 - 简介
落妇新苷（Lutein）是一种天然的类胡萝卜素类化合物，它是植物中广泛存在的一种黄色色素。以下是落妇新苷的性质、用途、制法和安全信息的介绍：
性质：
- 落妇新苷为黄色结晶粉末，不溶于水，溶于有机溶剂如氯仿、正己烷和二氯甲烷。
- 它是一种强效的抗氧化剂，可中和自由基，防止细胞氧化。
- 落妇新苷具有良好的稳定性，在高温和光照下不易分解。
用途：
- 在保健品领域，落妇新苷被用作视力保护和眼睛健康的补充剂。
制法：
- 落妇新苷主要从天然来源中提取，如马鞭草、玉米和番茄等。
- 提取方法通常包括溶剂提取和色谱纯化等步骤。
安全信息：
- 落妇新苷在推荐的剂量范围内被认为是安全的，但使用过量可能导致背部、头晕、恶心和呕吐等不适症状。
- 对于孕妇、哺乳期妇女以及过敏体质的人群，使用前应咨询医生的意见。
- 使用前应仔细阅读产品标签和使用指南，并遵循正确的剂量和使用方法。
性质：
- 落妇新苷为黄色结晶粉末，不溶于水，溶于有机溶剂如氯仿、正己烷和二氯甲烷。
- 它是一种强效的抗氧化剂，可中和自由基，防止细胞氧化。
- 落妇新苷具有良好的稳定性，在高温和光照下不易分解。
用途：
- 在保健品领域，落妇新苷被用作视力保护和眼睛健康的补充剂。
制法：
- 落妇新苷主要从天然来源中提取，如马鞭草、玉米和番茄等。
- 提取方法通常包括溶剂提取和色谱纯化等步骤。
安全信息：
- 落妇新苷在推荐的剂量范围内被认为是安全的，但使用过量可能导致背部、头晕、恶心和呕吐等不适症状。
- 对于孕妇、哺乳期妇女以及过敏体质的人群，使用前应咨询医生的意见。
- 使用前应仔细阅读产品标签和使用指南，并遵循正确的剂量和使用方法。
最后更新：2024-04-09 02:00:08
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产品名: 落新妇苷 紫外分光标准品 去供应商网站查看 询盘CAS: 29838-67-3
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包装: 20mg /瓶
规格: SVA1275-20mg
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产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格
产品名: 落新妇苷 紫外分光标准品 去供应商网站查看 询盘CAS: 29838-67-3
产地: 北京
包装: 20mg /瓶
规格: SVA1275-20mg
价格: 电话、微信、QQ、邮件
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
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