CBS9106 由BOC Sciences提供
联系方式
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| 公司名 | BOC Sciences |
| 联系人 | Linna Green |
| 电 话 | +16314854226 |
| 手 机 | +16314854226 |
| 电子邮件 | info@bocsci.com |
| 网 址 | http://www.bocsci.com/ |
| 地 区 | 其他 |
| 邮 编 | 11967 |
在线询盘
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向其他CBS9106供应商询盘
品名: CBS-9106
CAS: 1076235-04-5
规格: 99.09%
包装: 100mg；50mg；5mg；25mg；10mg；1mg
价格: 电话、微信、QQ、邮件
产地: 上海
最后更新: 2025-10-14 16:05:23
CAS: 1076235-04-5
规格: 99.09%
包装: 100mg；50mg；5mg；25mg；10mg；1mg
价格: 电话、微信、QQ、邮件
产地: 上海
最后更新: 2025-10-14 16:05:23
品名: CBS-9106
CAS: 1076235-04-5
包装: 50mg
价格: 面议、电联、微信、QQ
产地: 中国上海
最后更新: 2025-09-29 14:16:49
CAS: 1076235-04-5
包装: 50mg
价格: 面议、电联、微信、QQ
产地: 中国上海
最后更新: 2025-09-29 14:16:49
品名: CBS9106
CAS: 1076235-04-5
规格: C884670
包装: 100mg
价格: 100mg:8574
最后更新: 2025-08-29 22:21:42
CAS: 1076235-04-5
规格: C884670
包装: 100mg
价格: 100mg:8574
最后更新: 2025-08-29 22:21:42
品名: Felezonexor
CAS: 1076235-04-5
规格: HY-108716
包装: 1 mg;5 mg
产地: 美国
最后更新: 2025-10-14 16:03:33
CAS: 1076235-04-5
规格: HY-108716
包装: 1 mg;5 mg
产地: 美国
最后更新: 2025-10-14 16:03:33
CBS9106的基本信息
| 中文名 | CBS9106 |
| 英文名 | CBS9106 |
| 别名 | |
| CAS | 1076235-04-5 |
| EINECS | |
| 化学式 | C18H21ClF3N3O3 |
| 分子量 | 419.83 |
| inchi | |
| 包装信息 | 10 mg |
| 价格 | $1,198 |
| 产品描述 | CBS9106 CBS9106, also known as BMS-566419, is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. CBS9106 inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. CBS9106 reduces CRM1 protein levels significantly without affecting CRM1 mRNA expression. Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. Taken together, these results indicate that CBS9106 is a novel reversible CRM1 inhibitor and a promising clinical candidate. |
| 产品链接 | http://www.bocsci.com/product/cbs9106-cas-1076235-04-5-462313.html |
| 更新日期 | 2025-04-30 11:27:47 |
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