EPZ-6438; E-7438 MedChemExpress (MCE)

Product Name	EPZ-6438
Synonyms	E-7438 EPZ-6438 EPZ-7438 TazemetostatEPZ-6438 Henagliflozin Proline N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-[1,1'-biphenyl]-3-carboxamide Synonyms E-7438 EPZ-6438 EPZ-7438 TazemetostatEPZ-6438 Henagliflozin Proline N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-[1,1'-biphenyl]-3-carboxamide [1,1'-Biphenyl]-3-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)- N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-[1,1'-biphenyl]-3-carboxamide EPZ6438
CAS	1403254-99-8
EINECS
Chemical Formula	C34H44N4O4
Molecular Weight	572.74
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg;200 mg
Price	Email to quote
Descriptions	Tazemetostat Tazemetostat MedChemExpress (MCE) HY-13803 1403254-99-8 EPZ-6438 Descriptions Tazemetostat Tazemetostat MedChemExpress (MCE) HY-13803 1403254-99-8 EPZ-6438 E-7438 99.93% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US may vary elsewhere. Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Tazemetostat (EPZ-6438) inhibits multi wild-type and mutant lymphoma cell lines proliferation with IC50s of 0.49 nM-7.6 μM[1]. Tazemetostat (EPZ-6438 250 or 500 mg/kg twice daily for 21-28 days) practically eliminates the fast-growing G401 tumors[1]. EZH2 \| \| \| \| \| \| \| \| \| \| [1]. Knutson SK, et, al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferaseEZH2. Proc Natl Acad Sci U S A. 2013 May 7 110(19):7922-7. [Content Brief]
Supplier Website	http://www.medchemexpress.com/EPZ-6438.html
Last Update	2025-10-14 16:03:33

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-10-14 16:03:33

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-10-14 16:03:33

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-10-14 16:03:33

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-10-14 16:03:33

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-10-14 16:03:33

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-10-14 16:03:33

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-10-14 16:03:33

Thalidomide-PEG4-NH2

Category: Signaling Pathways
CAS: 2387510-82-7
Last Update: 2025-10-14 16:03:33


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	http://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact