TAK-242; CLI-095 MedChemExpress (MCE)

Product Name	RESATORVID
Synonyms	TAK 242 RESATORVID Resatorvid(TAK-242) TAK-242(Resatorvid) (R)-ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid ethyl ester Synonyms TAK 242 RESATORVID Resatorvid(TAK-242) TAK-242(Resatorvid) (R)-ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid ethyl ester Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-, ethyl ester, (6R)- 1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester, (6R)-
CAS	243984-11-4
EINECS
Chemical Formula	C15H17ClFNO4S
Molecular Weight	361.82
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Resatorvid Resatorvid MedChemExpress (MCE) HY-11109 243984-11-4 TAK-242 Descriptions Resatorvid Resatorvid MedChemExpress (MCE) HY-11109 243984-11-4 TAK-242 CLI-095 99.10% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases. Resatorvid suppresses the production of NO, TNF-α, and IL-6 from LPS-stimulated human peripheral blood mononuclear cells (PBMCs) at IC50 values from 11 to 33 nM[1]. Resatorvid (1-100 nM 4 hours) inhibits mRNA expression of IL-6 and TNF-α induced by LPS and IFN-γ in RAW264.7 cells[1]. Resatorvid (1-100 nM 15 minutes PBMCs cells) markedly inhibits the LPS-induced phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2), p38, and JNK/SAPK as well as degradation of IκBβ at a concentration of 100 nM[1]. Resatorvid (TAK-242 3 mg/kg intraperitoneal injection for 2 days male C57BL/6 mice) pretreatment markedly and significantly reverses the LPS-induced body weight loss, TA muscle loss, and muscle strength loss. TAK-242 reverses the LPS-induced shrinkage of muscle fibres and increases the interstitial space. TAK-242 blocks systemic catabolic cytokine release and skeletal muscle proteolysis in LPS-administered mice[3]. TLR4 TNF-R 1.9 nM (IC50) IL-6 1.3 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Ii M, et al. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. [Content Brief] [2]. Yamada M, et al. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. J Med Chem. 2005 Nov 17 48(23):7457-67. [Content Brief] [3]. Yuko Ono, et al. TAK-242, a Specific Inhibitor of Toll-like Receptor 4 Signalling, Prevents Endotoxemia-Induced Skeletal Muscle Wasting in Mice. Sci Rep. 2020 Jan 20 10(1):694. [Content Brief]
Supplier Website	http://www.medchemexpress.com/TAK-242.html
Last Update	2025-10-14 16:03:33

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-10-14 16:03:33

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-10-14 16:03:33

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-10-14 16:03:33

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-10-14 16:03:33

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-10-14 16:03:33

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-10-14 16:03:33

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-10-14 16:03:33

Thalidomide-PEG4-NH2

Category: Signaling Pathways
CAS: 2387510-82-7
Last Update: 2025-10-14 16:03:33


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	http://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact