MK-2206 (2HCl) MedChemExpress (MCE)

Product Name	MK-2206
Synonyms	CS-260 MK2206 MK-2206 MK-2206 MK 2206 MK2206 2HCL MK2206 HCL. Synonyms CS-260 MK2206 MK-2206 MK-2206 MK 2206 MK2206 2HCL MK2206 HCL. MK 2206 2HCL MK-2206 Dihydrochloride MK2206 DIHYDROCHLORIDE 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one 8-[4-(1-AMinocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Hydrochloride 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
CAS	1032350-13-2
EINECS
Chemical Formula	C25H21N5O
Molecular Weight	407.46714
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	MK-2206 dihydrochloride MK-2206 dihydrochloride MedChemExpress (MCE) HY-10358 1032350-13-2 MK-2206 (2HCl) 99.93% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions MK-2206 dihydrochloride MK-2206 dihydrochloride MedChemExpress (MCE) HY-10358 1032350-13-2 MK-2206 (2HCl) 99.93% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active, BBB-penetrated allosteric AKT inhibitor with IC50s of 5 nM, 12 nM, and 65 nM for AKT1, AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy. MK-2206 dihydrochloride (MK-2206 (2HCl)) (0-10 μM 72 and 96 hours) inhibits the nasopharyngeal carcinoma (NPC) cell lines CNE-1, CNE-2, HONE-1, and SUNE-1 proliferation in dose- and time-dependent manner[1]. MK-2206 dihydrochloride (0-10 μM 24 and 48 hours) results in a dose-dependent increase in the percentage of cells in G0/G1 phase and a concomitant reduction of cell numbers in S phase in CNE-2 and HONE-1 cells[2]. MK-2206 dihydrochloride (0-10 μM 24 hours) attenuates phosphorylation levels of PRAS40 and S6 in a dose-dependent manner. MK-2206 does not effect phosphorylation of GSKα/β and AKT[2]. MK-2206 dihydrochloride (0-10 μM 24 hours) increases the appearance of LC3-II in CNE-2 cells dose-dependently. Microtubule-associated protein 1 LC3 is an essential autophagy protein[2]. Both MK-2206 dihydrochloride (MK-2206 (2HCl)) doses (oral gavage 480 mg/kg once a week and 240 mg/kg three times a week for 2 weeks) can inhibit the growth of human CNE-2 xenografts in nude mice. No other obvious toxicity is observed in mice[2]. MK-2206 dihydrochloride (orally 120 mg/kg alternate days for 3 weeks) significantly inhibits tumor growth in 3-5 week old athymic nude mice with GEO colon carcinoma cells[3]. Akt1 8 nM (IC50) Akt2 12 nM (IC50) Akt3 65 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Li Yan, et al. Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. 2009. [2]. Zhao YY, et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10 8:1827-37. [Content Brief] [3]. Agarwal E, et al. Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. BMC Cancer. 2014 Mar 1 14:145. [Content Brief]
Supplier Website	http://www.medchemexpress.com/MK-2206-dihydrochloride.html
Last Update	2025-10-14 16:03:33

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