CHIR-99021; CT99021 MedChemExpress (MCE)

Product Name	CHIR-99021
Synonyms	CT99021 CT-99021 CHIR99021 CHIR-99021 CHIR 99021 GSK-3 Inhibitor XVI CT 99021(CHIR 99021) Synonyms CT99021 CT-99021 CHIR99021 CHIR-99021 CHIR 99021 GSK-3 Inhibitor XVI CT 99021(CHIR 99021) 6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile 6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile 3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]
CAS	252917-06-9
EINECS	809-015-4
Chemical Formula	C22H18Cl2N8
Molecular Weight	465.34
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Laduviglusib Laduviglusib MedChemExpress (MCE) HY-10182 252917-06-9 CHIR-99021 Descriptions Laduviglusib Laduviglusib MedChemExpress (MCE) HY-10182 252917-06-9 CHIR-99021 CT99021 99.43% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US may vary elsewhere. Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy. Laduviglusib (1-10 μM, 3 days) reduces the viability of the ES-D3 cells with an IC50 of 4.9 μM[2]. Laduviglusib (5 μM, 48 h) activates the canonical Wnt-pathway in ES-D3 cells and ES-CCE cells[2]. Laduviglusib (3 μM, 4 days) inhibits ES cell differentiation into neural cells[3]. Laduviglusib (1 μM, 2 weeks) inhibits adipogenesis by blocking induction of C/EBPα and PPARγ in 3T3-L1 preadipocytes[4]. Laduviglusib (2.5 μM, 24 h) protects Lgr5+ cells against radiation-induced apoptosis[5]. Laduviglusib (30 mg/kg, p.o) rapidly lowers plasma glucose[1]. Laduviglusib (2 mg/kg, i.p.) protects mice against radiation-induced lethal GI injury[5]. GSK-3β 6.7 nM (IC50) GSK-3α 10 nM (IC50) cdc2 8800 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar 52(3):588-95. [Content Brief] [2]. Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29 7:273. [Content Brief] [3]. Ye S, et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012 7(4):e35892. [Content Brief] [4]. Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23 277(34):30998-1004. [Content Brief] [5]. Wang X, et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10 5:8566. [Content Brief]
Supplier Website	http://www.medchemexpress.com/laduviglusib.html
Last Update	2025-10-14 16:03:33

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