Stattic MedChemExpress (MCE)

Product Name	Stattic
Synonyms	Stattic AKOS 1001 1,1-DIOXO-6-NITROBENZO(B)THIOPHENE 6-Nitrobenzo[b]thiophene1,1-dioxide 6-Nitro-1-benzothiophene 1,1-dioxide 6-NITRO-1H-1LAMBDA6-BENZO[B]THIOPHENE-1,1-DIONE 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
CAS	19983-44-9
EINECS
Chemical Formula	C8H5NO4S
Molecular Weight	211.19
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Stattic Stattic MedChemExpress (MCE) HY-13818 19983-44-9 99.58% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Stattic Stattic MedChemExpress (MCE) HY-13818 19983-44-9 99.58% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727). Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice. Stattic (20 μM 24 hours) inhibits STAT3 phosphorylation (Y705) and selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines[1]. Stattic (2.5, 5, 10 μM for 4 h) significantly reduces the nuclear level of pSTAT3 and survivin in PC3M-1E8 cells at 10 μM. Stattic (2.5-10 μM for 24 h) inhibits IL-6-induced STAT3 activation in a dose-dependent manner[2]. Stattic (2.5, 5, 10 μM for 48 h) suppresses both the growth and induces apoptosis prostate cancer cells (PC3M-1E8 cells) with 10 μM. Stattic does not induce significant cell apoptosis with 2.5 μM, 5 μM[2]. Stattic (2.5, 5, 10 μM for 48 h) shows significant S phase accumulation[2]. Stattic can not lead to significant morphological changes or apoptosis and has little STAT3 phosphorylation in A2780 cells and HUVECs[2]. Stattic (10 mg/kg i.p. three times per week for 10 week) ameliorates the renal dysfunction in Alport syndrome (AS) mice[3]. STAT3 \| \| \| \| \| \| \| \| \| \| [1]. Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12. [Content Brief] [2]. John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov 13(11):1123-4. [Content Brief] [3]. Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1 33(2):214-223. [Content Brief]
Supplier Website	http://www.medchemexpress.com/Stattic.html
Last Update	2025-10-14 16:03:33

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