(R)-(-)-Phenylephrine; L-Phenylephrine MedChemExpress (MCE)

Product Name	(-)-Phenylephrine Base
Synonyms	Phenylephrine;L -PHENYLEPHRINE;(-)-Phenylephrine Base;(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol;(2R)-2-hydroxy-2-(3-hydroxyphenyl)-N-methylethanaminium chloride
CAS	59-42-7
EINECS	200-424-8
Chemical Formula	C9H13NO2
Molecular Weight	167.21
inchi	InChI=1/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
Package	10 mM * 1 mL;10 mM * 1 mL;500 mg;500 mg
Price	Email to quote
Descriptions	Phenylephrine Phenylephrine MedChemExpress (MCE) HY-B0769 59-42-7 (R)-(-)-Phenylephrine Descriptions Phenylephrine Phenylephrine MedChemExpress (MCE) HY-B0769 59-42-7 (R)-(-)-Phenylephrine L-Phenylephrine 99.98% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant. (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist with pKi values of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively[1][2]. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis[3]. Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes[4]. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema[5]. Rats: A total of 170 male Wistar rats are randomLy allocated into 17 groups (n=10) using random number tables. Short-term (40 minutes) mechanical ventilation with high tidal volume is performed to induce lung injury, impair active Na+ transport and lung liquid clearance in the rats. Unventilated rats serves as controls. To demonstrate the effect of phenylephrine on alveolar fluid clearance, phenylephrine at different concentrations (10, 1, 0.1, 0.01, and 0.001 μM) is injected into the alveolar space of the HVT ventilated rats[5]. α adrenergic receptor \| \| \| \| \| \| \| \| \| \| [1]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul 121(6):1127-35. [Content Brief] [2]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov 46(5):929-36. [Content Brief] [3]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1 21:502-13. [Content Brief] [4]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1 332 ( Pt 2):459-65. [Content Brief] [5]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar 28(1):1-6. [Content Brief]
Supplier Website	http://www.medchemexpress.com/_R_-_-_-Phenylephrine.html
Last Update	2025-10-14 16:03:33

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