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59-42-7

(-)-Phenylephrine Base

CAS: 59-42-7

Molecular Formula: C9H13NO2

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59-42-7 - Names and Identifiers

Name (-)-Phenylephrine Base
Synonyms Phenylephrine
L -PHENYLEPHRINE
(-)-Phenylephrine Base
(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol
(2R)-2-hydroxy-2-(3-hydroxyphenyl)-N-methylethanaminium chloride
CAS 59-42-7
EINECS 200-424-8
InChI InChI=1/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

59-42-7 - Physico-chemical Properties

Molecular FormulaC9H13NO2
Molar Mass167.21
Density1.1222 (rough estimate)
Melting Point171°C
Boling Point341.1°C at 760 mmHg
Flash Point163.4°C
Vapor Presure3.18E-05mmHg at 25°C
Storage Condition2-8℃
MDLMFCD00044749
Physical and Chemical PropertiesBioactive (R)-(-)-Phenylephrine are selective α1-adrenoceptor agonists, mainly used as decongestants.
UseAdrenaline-like drugs for surgery to extend the time of local anesthesia, nasal congestion, acute hypotension, infection and anaphylactic shock and other symptoms

59-42-7 - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
R41 - Risk of serious damage to eyes
R37/38 - Irritating to respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S39 - Wear eye / face protection.

59-42-7 - Upstream Downstream Industry

Raw Materials(±)-3-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol
L -PHENYLEPHRINE
Benzenemethanol, 3-methoxy-α-[(methylamino)methyl]-, (αR)-
3-Methoxybenzaldehyde
1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride
Downstream Products1,3-Oxazolidine
L -PHENYLEPHRINE

59-42-7 - Nature

Open Data Verified Data

This product is white or white crystalline powder, odorless, bitter; Contact with the air or sunlight, easy to Oxidative deterioration. This product is very slightly soluble in water, insoluble in ethanol, chloroform, ether, fatty oil or volatile oil; Soluble in mineral acid or sodium hydroxide solution, insoluble in ammonia solution or sodium carbonate solution. Epinephrine is mainly found in adrenal medullary chromaffin cells and is the main hormone of adrenal medulla. Medicinal products are extracted from the adrenal medulla of domestic animals or synthesized artificially. It is a, B receptor agonist, the and B receptors are very strong, so the effect is more complex and extensive. Due to the excitation of the pl receptor in the heart, the myocardial contractility is enhanced, the heart rate is accelerated, and the oxygen consumption of the myocardium is increased. The stimulation of a receptor can make the skin mucous membrane blood vessels and splanchnic blood vessels contract, while the coronary artery and skeletal muscle blood vessels are relaxed due to the stimulation of p2 receptor of vascular smooth muscle. Vasoconstrictor effect on the brain and lung is weak, sometimes due to increased blood pressure and passive expansion. Due to the excitation of bronchial smooth muscle p2 receptor and produce obvious expansion effect, especially when bronchospasm (such as bronchial asthma) is more obvious. Can be excited on the bronchial mucosa vascular smooth muscle a receptor, so that mucosal vasoconstriction, eliminate asthma mucosal edema, and improve ventilation. It has a significant effect on the metabolism of the body, can promote the decomposition of glycogen in the liver and skeletal muscle, increase the concentration of free fatty acids in the blood, increase the oxygen consumption of the body, and increase the body temperature.

Last Update：2024-01-02 23:10:35

59-42-7 - Preparation Method

Open Data Verified Data
  1. extraction, isolation and purification of adrenal medulla from domestic animals.
  2. Artificial synthesis.
Last Update：2022-01-01 11:16:36

59-42-7 - Application

Open Data Verified Data

adrenergic receptor agonists. It is used to relieve bronchial asthma, rescue anaphylactic shock, compatibility with local anesthetics and local hemostasis, urticaria, hay fever, serum reaction and other allergic diseases, glaucoma and so on.

Last Update：2025-08-19 16:24:40

59-42-7 - Safety

Open Data Verified Data
    Notable for pallor, restlessness, palpitation and Head Pain. Hypertension arteriosclerosis, hyperthyroidism, diabetes, narrow angle glaucoma patients are not used.
  • store under reduced pressure, seal and store in a cool place.
Last Update：2022-01-01 11:16:37
59-42-7
Supplier List
Shanghai Amole Biotechnology Co., Ltd.
Featured ProductsSpot supply
Product Name: Phenylephrine Request for quotation
CAS: 59-42-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
MedChemExpress (MCE)
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CAS: 59-42-7
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
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Product Name: Phenylephrine Visit Supplier Webpage Request for quotation
CAS: 59-42-7
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Email: product@acmec-e.com
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Changsha Changtang import and Export Co., Ltd.
Product Name: Phenylephrine Request for quotation
CAS: 59-42-7
Tel: +86 18942506900
Email: lilyqu@chemoway.com
Mobile: +86 18942506900
QQ: 3182628472 Click to send a QQ message
Wechat: +86 18942506900
WhatsApp: +86 18942506900
Linkedin: +86 18942506900
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Phenylephrine Visit Supplier Webpage Request for quotation
CAS: 59-42-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shanghai Amole Biotechnology Co., Ltd.
Featured ProductsSpot supply
Product Name: Phenylephrine Request for quotation
CAS: 59-42-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
MedChemExpress (MCE)
Featured ProductsMultiple SpecificationsSpot supply
Product Name: (R)-(-)-Phenylephrine; L-Phenylephrine Visit Supplier Webpage Request for quotation
CAS: 59-42-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Phenylephrine Visit Supplier Webpage Request for quotation
CAS: 59-42-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Changsha Changtang import and Export Co., Ltd.
Product Name: Phenylephrine Request for quotation
CAS: 59-42-7
Tel: +86 18942506900
Email: lilyqu@chemoway.com
Mobile: +86 18942506900
QQ: 3182628472 Click to send a QQ message
Wechat: +86 18942506900
WhatsApp: +86 18942506900
Linkedin: +86 18942506900
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Phenylephrine Visit Supplier Webpage Request for quotation
CAS: 59-42-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
59-42-7
Raw Materials for 59-42-7
(±)-3-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol
L -PHENYLEPHRINE
Benzenemethanol, 3-methoxy-α-[(methylamino)methyl]-, (αR)-
3-Methoxybenzaldehyde
1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride
Downstream Products for 59-42-7
1,3-Oxazolidine
L -PHENYLEPHRINE
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