Calcitriol MedChemExpress (MCE)

Product Name	1A,25-dihydroxycholecalciferol
Synonyms	Calcitriol 1,25-(OH)2-D3 1a,25-Dihydroxyvitamin 1,25-dihydroxyvitamin D3 Vitamin D3, 1a,25-Dihydroxy- 1ALPHA,25-DIHYDROXYVITAMIN D3 1alpha,25-Dihydroxyvitamin D3 Synonyms Calcitriol 1,25-(OH)2-D3 1a,25-Dihydroxyvitamin 1,25-dihydroxyvitamin D3 Vitamin D3, 1a,25-Dihydroxy- 1ALPHA,25-DIHYDROXYVITAMIN D3 1alpha,25-Dihydroxyvitamin D3 1α,25-dihydroxycholecalciferol 1A,25-dihydroxycholecalciferol 1ALPHA,25-DIHYDROXY-VITAMIN D8 VITAMIN D3, 1ALPHA,25-DIHYDROXY 1alpha,25-dihydroxycholecalciferol 1ALPHA,25-DIHYDROXYCHOLECALCIFEROL (1S,3R)-9,10-secocholesta-5,7,10-triene-1,3,25-triol (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol 9,10-SECOCHOLESTA-5Z,7E,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL (1S,3R,5Z,7E,14xi)-9,10-secocholesta-5,7,10-triene-1,3,25-triol (5z,7e)-(1s,3r)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol (1ALPHA,3BETA,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL (1R,5Z)-5-[(2E)-2-[(1R,7aR)-1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
CAS	32222-06-3
EINECS	250-963-8
Chemical Formula	C27H44O3
Molecular Weight	416.64
inchi	InChI=1/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24?,25+,27-/m1/s1
Package	1 mg;2 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Calcitriol Calcitriol MedChemExpress (MCE) HY-10002 32222-06-3 1,25-Dihydroxyvitamin D3 99.94% -20°C, protect from light, stored under nitrogen The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US Descriptions Calcitriol Calcitriol MedChemExpress (MCE) HY-10002 32222-06-3 1,25-Dihydroxyvitamin D3 99.94% -20°C, protect from light, stored under nitrogen The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US may vary elsewhere. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist. Calcitriol exerts antiproliferative effects on cervical cancer cells in vitro. Cells decrease by 12.8% when treated with 100 nM Calcitriol for 6 days, compare with control. Inhibition of cell proliferation becomes more pronounced with the increase in Calcitriol concentration. The decrease is 26.1% and 31.6% for 200 and 500 nM Calcitriol, respectively. Treatment with Calcitriol for 72 h induces an evident accumulation of cells in the G1 phase, with approximately 66.18% in 200 nM and 78.10% in 500 nM, compare with the control (24.36%). Calcitriol treatment significantly decreases HCCR-1 protein expression compare with the control in a time- and dose-dependent manner[1]. Calcitriol significantly increases ERα mRNA in a dose dependent manner with an EC50 of 9.8×10-9 M[2]. Chronic treatment with Calcitriol (150 ng/kg per day for 4.5 months) improves the relaxations (pD2: 6.30±0.09, Emax: 68.6±3.9% in Calcitriol-treated OVX, n=8). Renal blood flow in OVX rats is reduced in both kidneys, and the flow is restored by Calcitriol treatment. The increased expression of COX-2 and Thromboxane-prostanoid (TP) receptor in OVX rat renal arteries is reduced by chronic calcitriol administration[3]. High- and low-dose Calcitriol treatment significantly decreases the systolic blood pressure (SBP) in the fructose-fed rats by 14±4 and 9±4 mmHg, respectively, at Day 56. High-dose Calcitriol treatment (20 ng/kg per day) significantly increases serum ionized calcium level (1.44±0.05 mmol/L) compare with the other groups[4]. Adult female Sprague-Dawley rats weighing 200 to 220g are used in this study. Rats are housed in a temperature-controlled room (~23°C) with a 12-h light/dark cycle. The animals have free access to a standard diet and water. Ovariectomy (OVX) is performed on rats. At 6 months after the surgical procedure, the OVX rats are randomly assigned to either treatment with vehicle dimethyl sulfoxide (OVX+vehicle) or Calcitriol (150 ng/kg daily, OVX+calcitriol). Calcitriol treatment is given by oral gavage and lasted or 4.5 months. Blood pressure and serum Calcitriol level are measured[3]. HeLa S3 cells are plated at a density of 1,000 cells/well in 96-well plates of Dulbecco’s modified Eagle’s medium (DMEM) with 10% fetal bovine serum (FBS), treated with 1% ethanol (control) or various concentrations of Calcitriol (100, 200, and 500 nM) for 72 h. A Cell Counting Kit8 (CCK-8) is used to determine cell proliferation. At 24, 48, 72, 96, 120, and 144 h after culturing with 200 nM Calcitriol, cells are harvested for analysis. Three independent experiments are performed in quadruplicate[1]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Wang G, et al. Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression. Oncol Res. 2014 22(5-6):301-9. [Content Brief] [2]. Santos-Martínez N, et al. Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. BMC Cancer. 2014 Mar 29 14:230. [Content Brief] [3]. Dong J, et al. Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int. 2013 Jul 84(1):54-63. [Content Brief] [4]. Chou CL, et al. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 16 10(3):e0119843. [Content Brief]
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