Melatonin MedChemExpress (MCE)

Product Name	Melatonine
Synonyms	MLT Melatonin Melatonine L-Arabinitol Melatonin (AS) Melatonin solution MELATONINE FOR SYNTHESIS 5 G Synonyms MLT Melatonin Melatonine L-Arabinitol Melatonin (AS) Melatonin solution MELATONINE FOR SYNTHESIS 5 G MELATONINE FOR SYNTHESIS 1 G N-Acetyl-5-methoxytryptamine 3-N-Acetyl-5-methoxyl tryptamine Melatonin N-Acetyl-5-methoxytryptamine N-(2-(5-methoxyindol-3-yl)ethyl)acetamide Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)- N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE Melatonine,N-(2-(5-Methoxyindol-3-yl)ethyl)acetaMide
CAS	73-31-4;8041-44-9
EINECS	200-797-7
Chemical Formula	C13H16N2O2
Molecular Weight	232.28
inchi	InChI=1/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
Package	10 mM * 1 mL;500 mg;1 g;5 g
Price	Email to quote
Descriptions	Melatonin Melatonin MedChemExpress (MCE) HY-B0075 73-31-4 N-Acetyl-5-methoxytryptamine 99.93% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Melatonin Melatonin MedChemExpress (MCE) HY-B0075 73-31-4 N-Acetyl-5-methoxytryptamine 99.93% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress. Melatonin increases the levels of activated PTEN, RSK-1, mTOR and AMPKα kinases, mildly inhibits ERK-1/2 phosphorylation and Bad phosphorylation, significantly inhibits phosphorylations of S6 Ribosomal Protein, 4E-BP1, GSK-3α and GSK-3β, and slightly increases PRAS40 phosphorylation in animals[1]. Melatonin ameliorates the neurotoxiciy and astrocyte activation induced by Aβ1-42 in the cerebral cortex. Melatonin also blocks the reduction in Reelin and Dab1 expression induced by Aβ1-42[2]. Melatonin treatment and lack of NLRP3-/- share similar inhibition of NF-κB and NLRP3 signaling pathway in mice. Melatonin treatment and lack of NLRP3-/- share some patterns of clock genes expression, and improve cardiomyocytes morphology in mice[3]. A total of two sets of adult male C57BL/6j mice weighing 21-26 g are randomly assigned to one of four groups and treated with intraperitoneal (i.p.) delivery of (i) vehicle (50 μL isotonic saline/5% ethanol), (ii) melatonin (4 mg/kg, dissolved in 0.9% isotonic saline/5% ethanol), (iii) Wortmannin, and (iv) melatonin/Wortmannin immediately after reperfusion. In the first set, mice are exposed to 30 min of focal cerebral ischemia (FCI) and 72 h reperfusion for the evaluation of disseminate ischemic injury in the striatum, and signaling pathway analysis (n=7 per group). The second group of mice is exposed to 90 min of FCI and 24 h reperfusion for the analysis of infarct development, brain swelling and IgG extravasation (n=7 per group). Microbial Metabolite Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5 12:657-665 [Content Brief] [2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [Content Brief] [3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 [Content Brief] [4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14 23(6):986-998. [Content Brief] [5]. Zhi Chen, et al. Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress. J Ovarian Res. 2019 May 10 12(1):43. [Content Brief]
Supplier Website	http://www.medchemexpress.com/Melatonin.html
Last Update	2025-10-14 16:03:33

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