BAPTA-AM MedChemExpress (MCE)

Product Name	BAPTA-AM
Synonyms	CS-968 BAPTAAM BAPTA-AM BAPTA AM 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER 1,2-bis(2-aminophenoxy)ethane-n,n,n0, n0-tetraacetic Acid Tetrakis(acetoxymethyl Ester) Synonyms CS-968 BAPTAAM BAPTA-AM BAPTA AM 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER 1,2-bis(2-aminophenoxy)ethane-n,n,n0, n0-tetraacetic Acid Tetrakis(acetoxymethyl Ester) 1,2-bis(2-aminophenoxy)ethane-n,n,n0, n0-tetraacetic Acid Tetrakis(acetoxymethyl Ester) Glycine, n,n0-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[n-[2- [(acetyloxy)methoxy]-2-oxoethyl]-, Bis[(acetyloxy)methyl] ester Glycine, n,n0-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[n-[2- [(acetyloxy)methoxy]-2-oxoethyl]-, Bis[(acetyloxy)methyl] ester acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
CAS	126150-97-8
EINECS	634-129-4
Chemical Formula	C34H40N2O18
Molecular Weight	764.68
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Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	BAPTA-AM BAPTA-AM MedChemExpress (MCE) HY-100545 126150-97-8 99.23% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions BAPTA-AM BAPTA-AM MedChemExpress (MCE) HY-100545 126150-97-8 99.23% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. BAPTA-AM is a well-known membrane permeable Ca2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. BAPTA-AM inhibits neuronal Ca2+-activated K+ channel currents, and up-regulates the decreased cardiac sodium current (INa) density by chelating intracellular Ca2+[1]. BAPTA-AM (BAPTA/AM), an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. BAPTA-AM prevents free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA-AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10 μM BAPTA-AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr. Exposure of cortical cultures to 3-10 μM BAPTA-AM for 48-hr evoke dose-dependent neuronal damage[2]. Neuronal injury is quantitatively estimated by measuring lactate dehydrogenase (LDH) released from damaged cells into the bathing medium 24- or 48-hr after the 10 μM BAPTA/AM treatment. The morphological findings are confirmed by staining with neuron-specific enolase (NSE) antibody and tryphan blue[1]. Ca2+ chelator[1] IC50: 1.3 μM (hERG channel, in HEK 293 cells), 1.45 μM (hKv1.3, in HEK 293 cells), 1.23 μM (hKv1.5, in HEK 293 cells)[1] In Vitro BAPTA-AM inhibits neuronal Ca2+-activated K+ channel currents, and up-regulates the decreased cardiac sodium current (INa) density by chelating intracellular Ca2+[1]. BAPTA-AM (BAPTA/AM), an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. BAPTA-AM prevents free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA-AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10 μM BAPTA-AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr. Exposure of cortical cultures to 3-10 μM BAPTA-AM for 48-hr evoke dose-dependent neuronal damage[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BAPTA-AM Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Tang Q, et al. The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Biochem Pharmacol. 2007 Dec 3 74(11):1596-607. [Content Brief] [2]. Wie MB, et al. BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Nov 25(8):1641-59. [Content Brief]
Supplier Website	http://www.medchemexpress.com/BAPTA-AM.html
Last Update	2025-10-14 16:03:33

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