Thapsigargin MedChemExpress (MCE)

Product Name	Thapsigargin
Synonyms	Thapsigargin (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate Synonyms Thapsigargin (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]f uran-7-yl ester
CAS	67526-95-8
EINECS	614-076-3
Chemical Formula	C34H50O12
Molecular Weight	650.75
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Thapsigargin Thapsigargin MedChemExpress (MCE) HY-13433 67526-95-8 99.87% -20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Thapsigargin Thapsigargin MedChemExpress (MCE) HY-13433 67526-95-8 99.87% -20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types. Thapsigargin (0.001- 1 μM for 2 and 4 days) arrests cell proliferations in MH7A human rheumatoid arthritis synovial cells in a time- and dose-dependent manner[2].Thapsigargin (0.001- 1 μM for 2 and 4 days) induces cell apoptosis in MH7A cells in a time- and dose-dependent manner[2]. Thapsigargin (0.001- 1 μM for 2 and 4 days) impairs mTOR activity and leads to cyclin D1 expressions in MH7A cells[2]. Thapsigargin inhibits Ca2+ entry into human neutrophil granulocytes[1].Thapsigargin inhibits the carbachol-evoked [Ca2+]i-transients with (IC50=0.353 nM) or without (IC50=0.448 nM) a KCl-prestimulation, but an additional small component, with a much lower sensitivity (IC50=4814 nM), is observed in the absence of a KCl-prestimulation. In contrast, the KCl-evoked [Ca2+]i-transients displayed only one component with a very low sensitivity to Thapsigargin in both absence (IC50=3343 nM) and presence (IC50=6858 nM) of a carbachol-prestimulation[3].Thapsigargin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation[6]. Thapsigargin (Injection 0.25 ug/g, 0.5 ug/g and 1 ug/g 24 hours) significant increases of 2 to 5-fold in chemokine and pro-inflammatory expression. Thapsigargin is more sensitive to inducing a systemic immune response[4]. Ca2+-ATPase[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Geiszt M, et al. Thapsigargin inhibits Ca²⁺ entry into human neutrophil granulocytes. Biochem J. 1995 Jan 15 305 ( Pt 2):525-8. [Content Brief] [2]. Wang H, et al. Effects of thapsigargin on the proliferation and survival of human rheumatoid arthritis synovialcells. ScientificWorldJournal. 2014 Feb 9 2014:605416. [Content Brief] [3]. Garavito-Aguilar ZV, et al. Differential thapsigargin-sensitivities and interaction of Ca2+ stores in human SH-SY5Y neuroblastoma cells. Brain Res. 2004 Jun 18 1011(2):177-86. [Content Brief] [4]. Abdullahi A, et al. Modeling Acute ER Stress in Vivo and in Vitro. Shock. 2017 Apr 47(4):506-513. [Content Brief] [5]. Mohammed Samer Shaban, et al. Inhibiting coronavirus replication in cultured cells by chemical ER stress. bioRxiv 2020.08.26.266304 [6]. Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov 63:109358. [Content Brief]
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Last Update	2025-10-14 16:03:33

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