Coenzyme Q0 MedChemExpress (MCE)

Product Name	2,3-dimethoxy-5-methyl-1,4-benzoquinone
Synonyms	COENZYME Q 2,3-DIMETHOXYMETHYLBENZOQUINONE 2,3-DIMETHOXY-5-METHYLBENZOQUINONE 2,3-DIMETHOXY-5-METHYL-P-BENZOQUINONE 2,3-Dimethoxy-5-Methyl-P-Benzoquinone 2,3-DIMETHOXY-5-METHYL-1,4-BENZOQUINONE Synonyms COENZYME Q 2,3-DIMETHOXYMETHYLBENZOQUINONE 2,3-DIMETHOXY-5-METHYLBENZOQUINONE 2,3-DIMETHOXY-5-METHYL-P-BENZOQUINONE 2,3-Dimethoxy-5-Methyl-P-Benzoquinone 2,3-DIMETHOXY-5-METHYL-1,4-BENZOQUINONE 2,3-dimethoxy-5-methyl-1,4-benzoquinone 2,3-DIMETHOXYL-5-METHYL-1,4-BENZOQUINONE 2,3-dimethoxy-5-methyl-1,4-*benzoquinone 2,3-dimethoxy-5-methyl-2,5-cyclohexadiene-1,4-dione 2,3-dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione 2,5-CYCLOHEXADIENE-1,4-DIONE, 2,3-DIMETHOXY-5-METHYL-
CAS	605-94-7
EINECS	210-100-8
Chemical Formula	C9H10O4
Molecular Weight	182.17
inchi	InChI=1/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3
Package	10 mM * 1 mL;500 mg
Price	Email to quote
Descriptions	Coenzyme Q0 Coenzyme Q0 MedChemExpress (MCE) HY-W016412 605-94-7 CoQ0 99.88% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Coenzyme Q0 Coenzyme Q0 MedChemExpress (MCE) HY-W016412 605-94-7 CoQ0 99.88% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling. Coenzyme Q0 (0-40 μM 24 h) and inhibits viability and growth of human ovarian carcinoma cells[1]. Coenzyme Q0 (CoQ0) (0-30 μM 24 h SKOV-3 cells) has anti-proliferative activity through induction of G2/M cell-cycle arrest and reduction of cell-cycle regulatory proteins[1]. Coenzyme Q0 (CoQ0) (0-30 μM 0-30 min SKOV-3 cells) increases intracellular ROS levels to promote SKOV-3 cell death[1]. Coenzyme Q0 (CoQ0) (0-30 μM 24 h SKOV-3 cells) induces autophagy by increase accumulation of LC3-II, GFP-LC3 puncta, AVOs formation and Beclin-1/Bcl-2 dysregulation[1]. Coenzyme Q0 (CoQ0) (0-30 μM 24 h SKOV-3 cells) induces apoptosis by mitochondrial (caspase-3, PARP and Bax/Bcl-2 dysregulation) and ER stress (caspase-12 and Hsp70) signals[1]. Coenzyme Q0 (CoQ0) (30 μM 24 h SKOV-3 cells) suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms[1]. Coenzyme Q0 (CoQ0) (0-10 μM 0.5-18 h RAW264.7 cells) regulates NFκB/AP-1 activation and enhances Nrf2 stabilization[2]. Coenzyme Q0 (CoQ0) (5 μM 0-12 h EA.hy 926 cells) has anti-angiogenic activity in EA.hy 926 cells[3]. Coenzyme Q0 (CoQ0) (1.5 and 2.5 mg/kg i.p. once every four days, for 52 d) suppresses tumor growth in SKOV-3 xenografted nude mice[1]. Coenzyme Q0(CoQ0) (5 mg/kg p.o. for 4 h) has anti-inflammatory activities through Nrf2 activation and NFκB inhibition in liver and spleen of LPS-treated mice[2]. \| \| \| \| \| \| \| \| \| \| [1]. Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb 1859(2):246-61. [Content Brief] [2]. Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb 1859(2):246-61. [Content Brief] [3]. Yang HL, et, al. Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells. Biochem Pharmacol. 2015 Nov 1 98(1):144-56. [Content Brief]
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Last Update	2025-10-14 16:03:33

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