2. Immunology/Inflammation
  3. Glycoprotein VI
  4. 10P3Me

10P3Me 是一种 Glypican-3 (GPC3) 靶向探针，与人源靶点的 Ka 为 93.8 nM。10P3Me 对 GPC3 具有高结合亲和力，能够靶向 GPC3 阳性细胞，用于 PET 成像。10P3Me 在包括皮下异种移植模型和原位 HepG2-LUC 肝癌模型在内的 GPC3 阳性肿瘤组织中选择性聚集，实现病灶的精确定位。

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Custom Peptide Synthesis

10P3Me

10P3Me Chemical Structure

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10P3Me 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

10P3Me is a Glypican-3 (GPC3)-targeting probe with a Ka of 93.8 nM for the human target. 10P3Me exhibits high binding affinity to GPC3, targets GPC3-positive cells, and serves as an agent for PET imaging. 10P3Me selectively accumulates in GPC3-positive tumor tissues, including subcutaneous xenograft models and orthotopic HepG2-LUC liver cancer models, to achieve precise localization of lesions[1].

体外研究
(In Vitro)

10P3Me (1 μCi per well；0.5-4 h) 在 GPC3 高表达的 HepG2、Hep3B2.1−7 和 Huh−7 细胞中的摄取量显著高于 GPC3 低表达的 H1975 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

10P3Me 相关抗体:
体内研究
(In Vivo)

10P3Me (200−300 μCi；i.v.) 具有特异性的高肿瘤摄取率，并在 GPC3 高表达的皮下 HCC 异种移植模型中具有较长的滞留时间[1]。
10P3Me (150−200 μCi；i.v.) 在 HepG2 异种移植模型中表现出较高的肿瘤峰值摄取量和理想的肿瘤-肝脏比值[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (female, 4−6 weeks old, 18−22 g, subcutaneous xenograft hepatocellular carcinoma model)[1]
Dosage: 200−300 μCi
Administration: i.v.; static scans at 60 and 120 min post-injection
Result: Reached peak tumor uptake of 5.62% ID/mL at 1 h and 3.53% ID/mL at 2 h post-injection in HepG2 xenograft models.
Achieved SUVmean of 5.09% ID/mL at 1 h, which was 3.97 times higher than in GPC3-low H1975 models.
Markedly reduced tumor accumulation in blocking groups and H1975 models.
Animal Model: Athymic nude mice (female, 4−6 weeks old, 18−22 g, orthotopic xenograft hepatocellular carcinoma model)[1]
Dosage: 200−300 μCi
Administration: i.v.; PET imaging at 1 h post-injection
Result: Clearly localized intrahepatic tumor lesions in the left hepatic lobe via PET/CT imaging at 1 h post-injection, which was confirmed by surgical dissection.
Animal Model: Athymic nude mice (female, 4−6 weeks old, 18−22 g, subcutaneous xenograft hepatocellular carcinoma model)[1]
Dosage: 150−200 μCi
Administration: i.v.; assessed at 10, 30, 60, 120, and 240 min post-injection
Result: Reached peak tumor uptake of 6.92% ID/g at 30 min post-injection.
Achieved a tumor-to-liver ratio of 8.28 at 60 min post-injection.
分子量

2215.55

Formula

C101H151N23O29S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

10P3Me 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10P3MeGlycoprotein VIGPVIHuh?7 cellsHepG2 cellsHepG2-LUC liver tumor modelsGlypican-3recombinant human GPC3 proteinH1975 cellshepatocellular carcinomaGPC3Hep3B2.1?7 cellssubcutaneous HCC xenograft modelsInhibitorinhibitorinhibit

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目录号：
HY-P11618
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