2. Others Metabolic Enzyme/Protease NF-κB Apoptosis Immunology/Inflammation
  3. LDLR Glutathione Peroxidase Isotope-Labeled Compounds Reactive Oxygen Species (ROS) Ferroptosis
  4. 2-Acetamidophenol-d3

2-Acetamidophenol-d3  (Synonyms: Orthocetamol-d3)

目录号: HY-W015600S
产品使用指南 技术支持

2-Acetamidophenol-d3 (Orthocetamol-d3) 是氘标记的 2-Acetamidophenol (HY-W015600)。2-Acetamidophenol (Orthocetamol) 是一种靶向铁死亡 (ferroptosis) 和谷胱甘肽代谢途径的调节剂，是 Paracetamol (HY-66005) 的邻位区域异构体 (ortho-)。2-Acetamidophenol 具有抗动脉粥样硬化活性，抑制斑马鱼高脂血症模型中总胆固醇 (TC)、甘油三酯 (TG) 的 IC50 分别为 30 μM 和 40 μM。2-Acetamidophenol 通过上调谷胱甘肽合成相关基因 (如 GCLC、GCLM、GSS) 和铁离子转运基因 (如 FPN1、FTH) 的表达，降低细胞内活性氧 (ROS) 和亚铁离子 (Fe2+) 积累，增强谷胱甘肽过氧化物酶 GPX4 活性，从而抑制巨噬细胞吞噬氧化低密度脂蛋白 ox-LDL 及泡沫细胞生成。

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2-Acetamidophenol-d<sub>3</sub>

2-Acetamidophenol-d3 Chemical Structure

CAS No. : 122258-87-1

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Other Forms of 2-Acetamidophenol-d3:

2-Acetamidophenol-d3 相关抗体

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查看 Glutathione Peroxidase 亚型特异性产品:

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GPX1 GPX4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation[1][2].

产品应用

1. 该化合物可作为示踪剂。
2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
IC50 & Target

GPX4

 

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Acetamidophenol-d3 相关抗体:
分子量

154.18

Formula

C8H6D3NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-Acetamidophenol-d3 相关分类

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Keywords:

2-Acetamidophenol-d3122258-87-1Orthocetamol-d3LDLRGlutathione PeroxidaseIsotope-Labeled CompoundsReactive Oxygen Species (ROS)FerroptosisLow-density lipoprotein receptorInhibitorinhibitorinhibit

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