2. Cell Cycle/DNA Damage Apoptosis GPCR/G Protein Anti-infection
  3. IRE1 Apoptosis Arrestin CHIKV
  4. 3-Ethoxy-5,6-dibromosalicylaldehyde

3-ethoxy-5,6-dibromosalicylaldehyde 是一种强效、非竞争性、选择性 IRE1 (含 IRE1α) 抑制剂 (IC50 值：∼0.12 μM (hIRE1α-cyto)；6 μM (酵母 Ire1))。3-ethoxy-5,6-dibromosalicylaldehyde 可抑制 XBP-1 剪接。3-ethoxy-5,6-dibromosalicylaldehyde 诱导凋亡 (Apoptosis)。3-ethoxy-5,6-dibromosalicylaldehyde 上调 TXNIP 的 mRNA 表达水平，同时下调 TXN 的表达水平。3-ethoxy-5,6-dibromosalicylaldehyde 对胰腺癌具有抗癌活性。3-ethoxy-5,6-dibromosalicylaldehyde 可显著抑制 chikungunya 病毒的复制。

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3-Ethoxy-5,6-dibromosalicylaldehyde

3-Ethoxy-5,6-dibromosalicylaldehyde Chemical Structure

CAS No. : 20041-64-9

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3-Ethoxy-5,6-dibromosalicylaldehyde 相关抗体

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生物活性

3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor (IC50s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1). 3-ethoxy-5,6-dibromosalicylaldehyde inhibits XBP-1 splicing. 3-ethoxy-5,6-dibromosalicylaldehyde induces Apoptosis. 3-ethoxy-5,6-dibromosalicylaldehyde upregulates the mRNA expression level of TXNIP, while downregulating the expression level of TXN. 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer. 3-ethoxy-5,6-dibromosalicylaldehyde significantly inhibits chikungunya virus replication[1][2][3].

IC50 & Target

IC50s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1[1]
分子量

323.97

Formula

C9H8Br2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-Ethoxy-5,6-dibromosalicylaldehyde 相关分类

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Keywords:

3-Ethoxy-5,6-dibromosalicylaldehyde20041-64-9IRE1ApoptosisArrestinCHIKVInositol requiring enzyme 1Chikungunya viruspancreatic canceranticancerPanc0327Panc0403Inhibitorinhibitorinhibit

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