2. Immunology/Inflammation
  3. STING
  4. ABM5-OVA

ABM5-OVA 是一种 STING 激动剂-抗原偶联物，由 diABZI-Mal (HY-176541) 与 OVA(250-264) (HY-P11058) 偶联而成。ABM5-OVA 可将抗原精确递送至内质网，在内质网膜处实现了抗原、STING、蛋白酶体和抗原转运体的共定位。ABM5-OVA 在多种小鼠模型中诱导出强大且持久的抗原特异性 CD8+ T 细胞免疫应答，可用于疫苗佐剂的研究。

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ABM5-OVA

ABM5-OVA Chemical Structure

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ABM5-OVA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABM5-OVA is a STING agonist-antigen conjugate formed by the conjugation of diABZI-Mal (HY-176541) and OVA (250-264) (HY-P11058). ABM5-OVA precisely delivers antigens to the endoplasmic reticulum, enabling the colocalization of antigens, STING, proteasomes and antigen transporters at the endoplasmic reticulum membrane. ABM5-OVA induces robust and long-lasting antigen-specific CD8+ T-cell immune responses in various mouse models, and can be used for research on vaccine adjuvants[1].

体外研究
(In Vitro)

ABM5-OVA (24 h) 激活骨髓树突状细胞 (BMDCs)，其 EC50值为 980.8 nM[1]。
ABM5-OVA (0.5 μM；2-8 h) 可在 2 小时时就诱导骨髓树突状细胞 (BMDCs) 发生交叉呈递，4 小时时达到显著水平，8 小时时进一步升高[1]。
ABM5-OVA (50 nM；80 h) 可显著增强弱 OVA-i 表位的交叉呈递及 OT-I 细胞的扩增[1]。
ABM5-OVA (2.5 μM; 2 h) 可在表达 STING-Flag 的 HeLa 细胞中，将 OVA 肽靶向至与内质网 (ER) 共定位的 STING 微簇[1]。
ABM5-OVA (0.5 μM；作用 8 h) 可显著增强 FLT3L 培养的 BMDCs 中 cDC1 和 cDC2 的交叉提呈作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ABM5-OVA 相关抗体:

Immunofluorescence[1]

Cell Line: HeLa cells expressing STING-Flag
Concentration: 2.5 μM
Incubation Time: 2 h
Result: Induced STING microclusters that colocalized with the ER; OVA peptides colocalized with STING microclusters only in the presence of ABM5.
体内研究
(In Vivo)

ABM5-OVA (10 nmol/只；皮下注射；于第 0 天和第 1 天给药 2 次) 可在小鼠体内强效诱导 OVA 特异性 CD8+T 细胞应答，其效力依赖于 STING[1]。
ABM5-OVA (10 nmol/只；皮下注射；于第 0 天和第 14 天给药 2 次) 可对小鼠的 B16-OVA 黑色素瘤提供完全的预防性保护[1]。
ABM5-OVA (10 nmol/只；皮下注射；于第 4、11、18 天给药 3 次) 在小鼠体内对 B16-OVA 肿瘤和 E.G7-OVA 淋巴瘤表现出显著疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (6-8 weeks old, female)[1]
Dosage: 10 nmol per mouse
Administration: subcutaneous; 2 doses on days 0 and 14
Result: Induced a 9-fold increase in OVA-tetramer+ CD8+ T cells compared to diABZI + OVA.
Animal Model: C57BL/6 (6-8 weeks old, female)[1]
Dosage: 10 nmol per mouse
Administration: subcutaneous; 2 doses on days 0 and 14
Result: Prevented all mice from succumbing to disease for 5 weeks; showed no visible lung metastatic foci after intravenous B16-OVA challenge.
Animal Model: C57BL/6 (6-8 weeks old, female)[1]
Dosage: 10 nmol per mouse
Administration: subcutaneous; 3 doses on days 4, 11, 18
Result: Provided prolonged tumor inhibition; prevented 75% of mice from death; exhibited superior efficacy compared to diABZI + OVA.
Significantly inhibited tumor growth compared to diABZI + OVA.
分子量

2865.27

Formula

C132H194N34O36S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ABM5-OVA 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABM5-OVASTINGStimulator of Interferon GenesTMEM173MITAERISMPYSCD8+ T cellsendoplasmic reticulumB16-OVA melanomaTBK1ovalbumin peptideTAP1dendritic cellsE.G7-OVA lymphomaproteasomesInhibitorinhibitorinhibit

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ABM5-OVA
目录号：
HY-185186
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