2. Immunology/Inflammation
  3. CTLA-4
  4. ADU-1604

ADU-1604 是一种人源化 IgG1 CTLA-4 抗体。ADU-1604 能够结合 CTLA-4 上的一个独特表位，并完全阻断其与CD80和CD86的相互作用。ADU-1604 可增强人 T 细胞应答，并具有良好的耐受性特征。ADU-1604 可用于黑色素瘤研究。Controls: Human IgG1 kappa, Isotype Control (HY-P99001)。

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ADU-1604

ADU-1604 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

ADU-1604 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ADU-1604 is a humanized IgG1 CTLA-4 antibody. ADU-1604 binds to a unique epitope on CTLA-4 and achieves full blockade of both CD80 and CD86 interactions. ADU-1604 enhances human T cell responses. ADU-1604 demonstrates a favorable tolerability profile. ADU-1604 can be used for melanoma research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

CTLA4
体内研究
(In Vivo)

ADU-1604 (30 mg/kg，静脉注射，每周一次，持续 5 周) 在食蟹猴中耐受性良好[2]。
ADU-1604在全身给药和瘤内注射后，人源化非小细胞肺癌PDX模型中，均展现出与一种参考抗体相当的抗肿瘤疗效[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

1493  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ADU-1604 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADU-1604ADU1604ADU 1604CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152IgG1antibody antagonistmelanomaInhibitorinhibitorinhibit

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产品名称：
ADU-1604
目录号：
HY-P991952
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