2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 302

Antibacterial agent 302 是一种抗菌剂。Antibacterial agent 302 具有强效且广谱的抗菌活性。Antibacterial agent 302 无明显的溶血毒性和细胞毒性，且诱导耐药性的倾向较低。Antibacterial agent 302 通过破坏细菌细胞膜的完整性发挥其抗菌作用。Antibacterial agent 302 可用于细菌性角膜炎的研究。

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Antibacterial agent 302

Antibacterial agent 302 Chemical Structure

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Antibacterial agent 302 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 302 is an antibacterial agent. Antibacterial agent 302 shows a potent and broad-spectrum antibacterial activity. Antibacterial agent 302 has no significant hemolytic toxicity and cytotoxicity, and a low tendency to induce resistance. Antibacterial agent 302 exerts its antibacterial mechanism by disrupting the integrity of the bacterial cell membranes. Antibacterial agent 302 can be used for the study of bacterial keratitis[1].

IC50 & Target

HIF-1α

 

体外研究
(In Vitro)

Antibacterial agent 302 (Compound 27) 对革兰氏阳性菌 (表皮葡萄球菌 CMCC 26069，MIC = 0.39 μg/mL) 和革兰氏阴性菌 (肺炎克雷伯菌 ATCC 10031，MIC = 1.56 μg/mL) 均表现出良好的抗菌活性[1]。
Antibacterial agent 302 对兔红细胞 (RBC) 的溶血毒性低，安全性高[1]。
Antibacterial agent 302 (24 h) 对 HEK 293 细胞的 CC50 为 62.44 μg/mL，对 NCTC 克隆 929 细胞的 CC50 为 84.46 μg/mL，对 THLE-2 细胞和 HSC-T6 细胞的 CC50 分别为 60.99 μg/mL 和 61.17 μg/mL[1]。
Antibacterial agent 302 (21 天) 对金黄色葡萄球菌 ATCC 29213 和大肠杆菌 ATCC 25922 的最低抑菌浓度 (MIC) 值在 20 代以上保持稳定，且不易诱导耐药性[1]。
Antibacterial agent 302 (8 × MIC，2 小时) 通过破坏金黄色葡萄球菌 ATCC 29213、耐甲氧西林金黄色葡萄球菌 NCTC 10442 和大肠杆菌 ATCC 25922 的细胞膜发挥杀菌作用，并导致细菌形态损伤[1]。
Antibacterial agent 302 (1-8 × MIC，1 小时) 增加耐甲氧西林金黄色葡萄球菌 NCTC 10442 和铜绿假单胞菌 ATCC 9027 的细菌膜通透性，导致内容物泄漏[1]。
Antibacterial agent 302 (1-2 × MIC，1 小时) 能以浓度依赖的方式增加大肠杆菌外膜的通透性[1]。
Antibacterial agent 302 (4 × MIC，90 分钟) 分别使金黄色葡萄球菌 ATCC 29213 中 dltB、mprF 和 vraG 基因的表达上调 3.9 倍、3.1 倍和 4.9 倍[1]。
Antibacterial agent 302 (0.39-12.5 μg/mL，24 小时) 能有效抑制金黄色葡萄球菌 ATCC 29213 和大肠杆菌 ATCC 25922 的生物膜形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 302 相关抗体:

Cell Viability Assay[1]

Cell Line: Caco-2 cells
Concentration: 2.07 μM
Incubation Time: 72 h
Result: Suppressed Caco-2 cell migration with 56.29 % wound closure.

Cell Cycle Analysis[1]

Cell Line: Caco-2 cells
Concentration:
Incubation Time: 24 h and 48 h
Result: Increased of % Caco-2 cells in G0 / G1 phase from 62.07 % in the control to 86.36 %.
Reduced nearly 3-fold in % Caco-2 cells in both S phase and G2 / M phase.

Apoptosis Analysis[1]

Cell Line: Caco-2 cells
Concentration:
Incubation Time: 24 h and 48 h
Result: Increased 42 fold in total apoptosis
Increased the ratio of annexin V-FITC positive early apoptotic cells from 0.54 % to 20.26 %, whilst the percentage of late apoptotic cells rose from 0.22 % to 11 %.
Resulted in a combined percentage of early and late apoptotic cells that significantly exceeded the percentage of necrotic cells. (Early apoptotic cells is 20.26%, late apoptotic cells is 11.32%, necrotic cells is 3.61%).
体内研究
(In Vivo)

Antibacterial agent 302 (Compound 27) (5 mg/mL，局部用药，每日 4-6 次) 在体内对革兰氏阳性菌 (金黄色葡萄球菌) 和革兰氏阴性菌 (铜绿假单胞菌) 引起的角膜炎显示出显著疗效，且未在小鼠中观察到明显的毒性症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The left corneas of the C57BL/6 mice aged 6-8 weeks (with a weight of 16-18 g) were scratched with a sterile needle. The bacterial suspensions of S. aureus ATCC 29213 or P. aeruginosa ATCC 9027 were adjusted to a bacterial cell concentration of approximately 5× 107 CFU/mL and then dropped onto the injured corneas to establish a corneal infection model[1].
Dosage: 5 mg/mL
Administration: For S. aureus infection: Topical application, starting 24 hours after infection, four times daily (2-hour intervals) for three consecutive days.
For P. aeruginosa infection: Topical application, once every 20 minutes for the first hour after the first dose, then once every 2 hours (a total of six times daily) for two consecutive days.
Result: For S. aureus infection, corneal bacterial load decreased by 5.56 log.
For P. aeruginosa infection, bacterial load decreased by 2.20 log.
分子量

847.10

Formula

C44H70N12O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 302 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 302Antibacterial agent302Antibacterial agent-302BacterialIvacaftorAntimicrobial peptidomimeticsMembrane-targetingBroad-spectrumDrug resistanceInhibitorinhibitorinhibit

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