2. Others
  3. Drug Derivative
  4. Antitumor agent-208

Antitumor agent-208 是 Bufalin (HY-N0877) 的类似物，是一种强效且口服有效的抗肿瘤剂。Antitumor agent-208 对肿瘤细胞系具有抗增殖活性 (IC50 = 0.30-1.09 nM)。Antitumor agent-208 在 MV-4-11 异种移植小鼠模型中抑制肿瘤生长。Antitumor agent-208 可用于癌症研究，例如急性髓系白血病 (AML) 和非小细胞肺癌 (NSCLC)。

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Antitumor agent-208

Antitumor agent-208 Chemical Structure

CAS No. : 1385011-94-8

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Antitumor agent-208 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Antitumor agent-208, a Bufalin (HY-N0877) analogue, is a potent and orally active antitumor agent. Antitumor agent-208 exhibits antiproliferative activity against tumor cell line (IC50 =0.30-1.09 nM). Antitumor agent-208 inhibits tumor growth in a MV-4-11 xenograft mouse model. Antitumor agent-208 can be used for cancer research, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC)[1].

体外研究
(In Vitro)

Antitumor agent-208 (compound 3i) 对一系列人类肿瘤细胞系，包括 HeLa、HepG2、Daudi、MV-4-11、Jurkat、HT1080、PC-3、AGS、MCF-7 和 NCI-H2228 表现出强烈的抗增殖活性，其 IC50 值分别为 0.59、0.51、2.86、0.75、1.09、2.90、0.55、9.62、9.97 和 0.56 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-208 相关抗体:
分子量

512.68

Formula

C30H44N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-208 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-2081385011-94-8Antitumor agent208Antitumor agent 208Drug DerivativeDrug derivativeBufalinMV-4-11 xenograft mouse modelacute myeloid leukemianon-small cell lung cancerInhibitorinhibitorinhibit

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