2. Immunology/Inflammation
  3. IFNAR
  4. Antitumor agent-210

Antitumor agent-210 (Compound 1778) 是一种 NK 细胞激活剂。Antitumor agent-210 对 NK 92 细胞有微弱的促增殖作用，促进了 NK 细胞的活化和脱颗粒作用，可显著提高 NK 92 细胞杀伤肿瘤细胞的作用。Antitumor agent-210 促进细胞因子颗粒酶 B (granzyme B)、穿孔素 (perforin)、IFN-γ 释放。Antitumor agent-210 减少了小鼠肺部转移病灶的数量，可用于研究黑色素瘤肺转移。

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Antitumor agent-210

Antitumor agent-210 Chemical Structure

CAS No. : 2978670-53-8

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Antitumor agent-210 相关抗体

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  • 生物活性

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生物活性

Antitumor agent-210 (Compound 1778) is an NK cell activator. Antitumor agent-210 has a weak proliferative effect on NK92 cells, promoting the activation and degranulation of NK cells, and significantly enhancing the cytotoxicity of NK92 cells against tumor cells. Antitumor agent-210 promotes the release of cytokine granzyme B, perforin, and IFN-γ. Antitumor agent-210 reduces the number of lung metastatic lesions in mice and can be used for the study of melanoma lung metastasis[1].

分子量

544.00

Formula

C28H30ClNO8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-210 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-2102978670-53-8Antitumor agent210Antitumor agent 210IFNARInterferon-α/β receptorInterferon-alpha/beta receptorazaphilone compound preparationantitumor drugInhibitorinhibitorinhibit

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