2. Membrane Transporter/Ion Channel
  3. Aquaporin
  4. Aquaporumab

Aquaporumab (AQmabAM) 是一种工程化的人源单克隆 IgG 抗体。Aquaporumab 是选择性的水通道蛋白 4 (AQP4) 抑制剂，可与 AQP4 紧密结合，竞争性置换血清中的 AQP4-IgG 。Aquaporumab 可显著减少脊髓切片培养物以及接受脑内 AQP4-IgG 和补体注射的小鼠中的视神经脊髓炎病灶 。Aquaporumab 可用于视神经脊髓炎谱系疾病的研究 。

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Aquaporumab

Aquaporumab Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Aquaporumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aquaporumab (AQmabAM) is an engineered human monoclonal IgG antibody. Aquaporumab is a selective inhibitor of aquaporin 4 (AQP4), binding tightly to AQP4 and competitively displacing AQP4-IgG from serum [1][2]. Aquaporumab significantly reduces neuromyelitis optica lesions in spinal cord slice cultures and in mice receiving intracerebral injection of AQP4-IgG and complement [1][2]. Aquaporumab can be used for research on neuromyelitis optica spectrum disorders [1][2]."}

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

AQP4

 

体外研究
(In Vitro)

Aquaporumab 可竞争性置换视神经脊髓炎 (NMO) 血清中的 AQP4-IgG，并能阻止细胞毒性，从而减少脊髓切片培养物中的 NMO 病灶[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aquaporumab 相关抗体:
体内研究
(In Vivo)

Aquaporumab 可减少接受脑内 AQP4-IgG 和补体的小鼠的 NMO 病灶[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

361  [NCBI]

Accession

P55087
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aquaporumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AquaporumabAQmabAM rAb-53rAb53rAb 53rAb-53AquaporinAQPAQP4-IgGantibody-dependent cellular cytotoxicityspinal cord slice culturesmiceAquaporin-4NMO patient seraAQP4neuromyelitis optica spectrum disorderscomplement-dependent cytotoxicityNMO patient serum autoantibodiesInhibitorinhibitorinhibit

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目录号：
HY-P991869
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