2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs Bcr-Abl
  4. Azo-PROTAC-4C-cis

Azo-PROTAC-4C-cis 是一种 BCR-ABL PROTAC 降解剂，对 BCR-ABL 的降解效率远低于其反式异构体 Azo-PROTAC-4C-trans (HY-180983)。Azo-PROTAC-4C-cis 是 Azo-PROTAC-4C-trans 在紫外光 (UV) 照射下发生构型转换的产物。Azo-PROTAC-4C-cis 可在可见光下转换为高活性的 Azo-PROTAC-4C-trans，从而开始蛋白降解。Azo-PROTAC-4C-cis 可用于研究髓系白血病。
(粉色: Target Protein Ligand-Linker Conjugates 配体 (HY-107447)；蓝色: Ligands for E3 Ligase 和 Cereblon 配体 (HY-14658)；黑色: 连接子)。

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Azo-PROTAC-4C-cis

Azo-PROTAC-4C-cis Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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100 mg   询价  
250 mg   询价  

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Customer Review

Azo-PROTAC-4C-cis 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Bcr-Abl 亚型特异性产品:

查看所有亚型
Abl Bcr-Abl

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia[1]. (Pink: Target Protein Ligand-Linker Conjugates ligand (HY-107447); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-14658); Black: linker).

IC50 & Target[1]

Bcr-Abl

 

Cereblon

 

分子量

995.50

Formula

C50H47ClN12O7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Azo-PROTAC-4C-cis 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azo-PROTAC-4C-cisPROTACsBcr-AblAzo-PROTACprotein degradationphotoswitchableBCR-ABLcis-trans isomerizationlight controlubiquitin-proteasome systemreversible knockdownInhibitorinhibitorinhibit

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产品名称：
Azo-PROTAC-4C-cis
目录号：
HY-180985
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