2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. BE-10988

BE-10988 是一种 DNA 拓扑异构酶 (DNA topoisomerase) 抑制剂。BE-10988 通过增加 DNA 拓扑异构复合物的形成，抑制 Doxorubicin (HY-15142A) 耐药和长春新碱耐药的 P388 小鼠白血病细胞系的生长。

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BE-10988

BE-10988 Chemical Structure

CAS No. : 135261-89-1

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BE-10988 相关抗体

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Topoisomerase Topo I Topo II DNA gyrase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BE-10988 is a DNA topoisomerase inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SK-BR-3 IC50
8.7 μM
Compound: 1
The IC50 value was measured on human breast cancer cell line SK-BR-3.
The IC50 value was measured on human breast cancer cell line SK-BR-3.
[PMID: 7699696]
V79 IC50
5.1 μM
Compound: 1
The IC50 value was measured on V79 cells in the presence of nitrogen using MTT assay.
The IC50 value was measured on V79 cells in the presence of nitrogen using MTT assay.
[PMID: 7699696]
V79 IC50
6.2 μM
Compound: 1
The IC50 value was measured on V79 cells in the presence of air using MTT assay.
The IC50 value was measured on V79 cells in the presence of air using MTT assay.
[PMID: 7699696]
分子量

302.31

Formula

C13H10N4O3S
CAS 号
结构分类
初始来源

Actinomycetes
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BE-10988 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BE-10988135261-89-1BE10988BE 10988TopoisomeraseinhibitorDrug resistanceP388 mouse leukemia cell lineInhibitorinhibit

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产品名称：
BE-10988
目录号：
HY-167671
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