2. Apoptosis
  3. IAP
  4. BV6 TFA

BV6 TFA 是凋亡抑制蛋白 (IAP) 家族成员 cIAP1 和 XIAP 的拮抗剂。BV6 TFA 抑制 HCC193 细胞的增殖的 IC50 值为 7.2 μM，在 MTS 检测中。BV6 TFA 可用于子宫内膜癌和子宫内膜异位症的研究。

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规格 价格 是否有货 数量
1 mg ￥453
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5 mg ￥836
In-stock
10 mg ￥1440
In-stock
25 mg ￥2680
In-stock
50 mg ￥4288
In-stock
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Customer Review

Other Forms of BV6 TFA:

BV6 TFA 相关抗体

Top Publications Citing Use of Products

    BV6 TFA purchased from MCE. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136.   [Abstract]

    Western Blot analysis of p52, p100, NIK, c-IAP2, Peli1, and HSP60 in total lysis of control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, and then stimulated with anti-CD40 (αCD40) at the indicated time points.

    BV6 TFA purchased from MCE. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136.   [Abstract]

    Western Blot analysis of p52, p100, NIK, c-IAP2, Peli1, and HSP60 in total lysis of control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, and then stimulated with BAFF at the indicated time points.

    BV6 TFA purchased from MCE. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136.   [Abstract]

    Analysis of Lys48 ubiquitination of NIK in control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, then left unstimulated or stimulated with anti-CD40 (αCD40) for 4 h in the presence of MG132.

    查看 IAP 亚型特异性产品:

    查看所有亚型
    cIAP cIAP-1 cIAP-2 XIAP

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    BV6 TFA is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 TFA shows an IC50 of 7.2 μM in MTS assays in HCC193 cells. BV6 TFA can be used in the research of endometrial cancer and endometriosis[1][2].

    体外研究
    (In Vitro)

    BV6 TFA (250 nM-30 μM, 24 h) 以浓度和时间依赖性方式诱导 HCC193 和 H460 肺癌细胞凋亡。BV6 TFA 还可以增强 HCC193 和 H460 细胞对放射线的敏感性[1]。
    BV6 TFA (1μM 24 h; 5 μM, 48 h) 显著增强细胞对放射线的敏感性 (HCC193：在 1 μM BV6 浓度下，剂量增强比 DER=1.38；H460：在 5 μM BV6 浓度下，剂量增强比 DER=1.42)[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    BV6 TFA 相关抗体:

    Cell Proliferation Assay[1]

    Cell Line: HCC193 cells, H460 cells
    Concentration: 250 nM, 500 nM, 1 μM, 3 μM, 5 μM, 10 μM, 20 μM, 30 μM
    Incubation Time: 24 hours
    Result: Decreased cell survival percentage for HCC193 with an IC50 of 7.2μM.
    Decreased the cell viability of H460 cells by about 60% at 30 μM.

    Western Blot Analysis[1]

    Cell Line: HCC193 cells, H460 cells
    Concentration: 0.25 μM, 0.5 μM, 1 μM, 5 μM
    Incubation Time: 1, 14, 24 hours
    Result: Reduced the expression of cIAP1 within one hour and gradually decreased XIAP with increased incubation time for both cell lines.
    Reduced the expression of cIAP1 with 0.25μM and gradually decreased XIAP with increasing concentration for both cell lines.

    ELISA Assay[1]

    Cell Line: HCC193 cells, H460 cells
    Concentration: 1 μM, 5 μM
    Incubation Time: 12 hours
    Result: Induced enhancement of the secretion of TNFα in HCC193 cells.
    Did not enhance the secretion of TNFα in H460 cells.
    体内研究
    (In Vivo)

    BV6 TFA (10 mg/kg, twice weekly for 4 weeks, i.p.) 可减弱 IAPs 的表达强度。 BV6 TFA (10 mg/kg, twice weekly for 4 weeks, i.p.) 可减少病灶总数和 Ki67 阳性细胞的百分比与对照组相比。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female endometriosis mice modeling by Estradiol valerate (HY-B0672) at the dosage 0.5 µg/mouse/week s.c injected (6 weeks of age, BALB/c).
    Dosage: 10 mg/kg
    Administration: a single i.p. injection,twice weekly for 4 weeks
    Result: Attenuated the intensity of IAPs expression.
    分子量

    1205.57 (free base)

    Formula

    C70H96N10O8·xC2HF3O2
    性状

    固体

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    纯度 & 产品资料
    参考文献

    BV6 TFA 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BV6BV 6BV-6IAPcIAP1XIAPapoptosisHCC193Inhibitorinhibitorinhibit

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