2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Carbonic Anhydrase Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis
  4. CAII-IN-11

CAII-IN-11 (Compound A1) 是一种双靶点化合物，含有一个 hCA II 抑制剂 (IC₅₀ = 2 nM) 的部分和 NO 供体部分。CAII-IN-11 对 hCA IX、hCA XII 和 hCA I 也具有抑制活性，其 IC50 分别为 6、3 和 152 nM。CAII-IN-11 能显著升高人小梁网细胞内的 cGMP 水平。CAII-IN-11 通过减少氧化应激 (ROS 水平)、抑制星形胶质细胞和 NLRP3 炎性小体激活来减少视网膜神经节细胞的凋亡 (apoptosis)。CAII-IN-11 在家兔模型中具有降眼压活性，可用于研究青光眼。

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CAII-IN-11

CAII-IN-11 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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Customer Review

CAII-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA IX CA XII

查看 NOD-like Receptor (NLR) 亚型特异性产品:

查看所有亚型
NLRP3 NLRP1 NOD1 NOD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAII-IN-11 (Compound A1) is a dual-target compound that contains a hCA II inhibitor (IC₅₀ = 2 nM) portion and a NO donor portion. CAII-IN-11 also has inhibitory activity against hCA IX, hCA XII, and hCA I, with IC50 values of 6, 3, and 152 nM respectively. CAII-IN-11 significantly increases the intracellular cGMP level in human trabecular meshwork cells. CAII-IN-11 reduces the apoptosis of retinal ganglion cells by reducing oxidative stress (ROS levels), inhibiting astrocytes and the NLRP3 inflammasome activation. CAII-IN-11 has hypotensive activity in rabbit models and can be used for the study of glaucoma[1].

IC50 & Target[1]

hCA II

2 nM (IC50)

hCA XII

3 nM (IC50)

hCA IX

6 nM (IC50)

hCA I

152 nM (IC50)

NLRP3 inflammasome

 

分子量

374.32

Formula

C13H14N2O9S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CAII-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAII-IN-11Carbonic AnhydraseReactive Oxygen Species (ROS)NOD-like Receptor (NLR)ApoptosisCarbonate dehydrataseDual-targethCA II inhibitorNitric oxide donorIntraocular pressureRetinal ganglion cellsNeuroprotectionOcular metabolismSafety profileInhibitorinhibitorinhibit

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